The microbiome and blood pressure: Can microbes regulate our blood pressure?

Souhaila M. Al Khodor, Bernd Reichert, Ibrahim F. Shatat

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

The surfaces of the human body are heavily populated by a highly diverse microbial ecosystem termed the microbiota. The largest and richest among these highly heterogeneous populations of microbes is the gut microbiota. The collection of microbes and their genes, called the microbiome, has been studied intensely through the past few years using novel metagenomics, metatranscriptomics, and metabolomics approaches. This has enhanced our understanding of how the microbiome affects our metabolic, immunologic, neurologic, and endocrine homeostasis. Hypertension is a leading cause of cardiovascular disease worldwide; it contributes to stroke, heart disease, kidney failure, premature death, and disability. Recently, studies in humans and animals have shown that alterations in microbiota and its metabolites are associated with hypertension and atherosclerosis. In this review, we compile the recent findings and hypotheses describing the interplay between the microbiome and blood pressure, and we highlight some prospects by which utilization of microbiome-related techniques may be incorporated to better understand the pathophysiology and treatment of hypertension.

Original languageEnglish
Article number138
JournalFrontiers in Pediatrics
Volume5
DOIs
Publication statusPublished - 19 Jun 2017

Fingerprint

Microbiota
Blood Pressure
Hypertension
Metagenomics
Premature Mortality
Metabolomics
Human Body
Nervous System
Renal Insufficiency
Ecosystem
Heart Diseases
Atherosclerosis
Homeostasis
Cardiovascular Diseases
Stroke
Population
Genes

Keywords

  • Blood pressure
  • Dysbiosis
  • Hypertension
  • Lifestyle
  • Microbial metabolites
  • Microbiota
  • Short-chain fatty acid

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

The microbiome and blood pressure : Can microbes regulate our blood pressure? / Al Khodor, Souhaila M.; Reichert, Bernd; Shatat, Ibrahim F.

In: Frontiers in Pediatrics, Vol. 5, 138, 19.06.2017.

Research output: Contribution to journalReview article

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