The LH/FSH ratio has little use in diagnosing polycystic ovarian syndrome

Li Wei Cho, Vijay Jayagopal, Eric S. Kilpatrick, Stephen Holding, Stephen Atkin

Research output: Contribution to journalArticle

25 Citations (Scopus)


Background: The luteinizing hormone/follicle stimulating hormone (LH/FSH) ratio is often requested to help diagnose polycystic ovarian syndrome (PCOS) despite a recent consensus recommending against its use. This study aimed to compare the variability of the LH/FSH ratio in PCOS with that of normal menstruating women over a full cycle in order to establish the diagnostic utility, or otherwise, of the test. Methods: Twelve women with PCOS and 11 matched controls had blood collected at four-day intervals on 10 consecutive occasions over a complete menstrual cycle. Results: The median LH/FSH ratio for individual subjects did not differ significantly between the PCOS and the non-affected group (1.6 versus 1.2, P=0.14). Only 7.6% of samples from PCOS patients had an LH/FSH ratio above three, compared with 15.6% of samples from normal subjects. Conclusion: This study confirms that measurement of the LH/FSH ratio is of limited use in the diagnosis of PCOS.

Original languageEnglish
Pages (from-to)217-219
Number of pages3
JournalAnnals of Clinical Biochemistry
Issue number3
Publication statusPublished - May 2006
Externally publishedYes


ASJC Scopus subject areas

  • Clinical Biochemistry

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