Abstract
Background: The luteinizing hormone/follicle stimulating hormone (LH/FSH) ratio is often requested to help diagnose polycystic ovarian syndrome (PCOS) despite a recent consensus recommending against its use. This study aimed to compare the variability of the LH/FSH ratio in PCOS with that of normal menstruating women over a full cycle in order to establish the diagnostic utility, or otherwise, of the test. Methods: Twelve women with PCOS and 11 matched controls had blood collected at four-day intervals on 10 consecutive occasions over a complete menstrual cycle. Results: The median LH/FSH ratio for individual subjects did not differ significantly between the PCOS and the non-affected group (1.6 versus 1.2, P=0.14). Only 7.6% of samples from PCOS patients had an LH/FSH ratio above three, compared with 15.6% of samples from normal subjects. Conclusion: This study confirms that measurement of the LH/FSH ratio is of limited use in the diagnosis of PCOS.
| Original language | English |
|---|---|
| Pages (from-to) | 217-219 |
| Number of pages | 3 |
| Journal | Annals of Clinical Biochemistry |
| Volume | 43 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - May 2006 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Clinical Biochemistry
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The LH/FSH ratio has little use in diagnosing polycystic ovarian syndrome. / Cho, Li Wei; Jayagopal, Vijay; Kilpatrick, Eric S.; Holding, Stephen; Atkin, Stephen.
In: Annals of Clinical Biochemistry, Vol. 43, No. 3, 05.2006, p. 217-219.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The LH/FSH ratio has little use in diagnosing polycystic ovarian syndrome
AU - Cho, Li Wei
AU - Jayagopal, Vijay
AU - Kilpatrick, Eric S.
AU - Holding, Stephen
AU - Atkin, Stephen
PY - 2006/5
Y1 - 2006/5
N2 - Background: The luteinizing hormone/follicle stimulating hormone (LH/FSH) ratio is often requested to help diagnose polycystic ovarian syndrome (PCOS) despite a recent consensus recommending against its use. This study aimed to compare the variability of the LH/FSH ratio in PCOS with that of normal menstruating women over a full cycle in order to establish the diagnostic utility, or otherwise, of the test. Methods: Twelve women with PCOS and 11 matched controls had blood collected at four-day intervals on 10 consecutive occasions over a complete menstrual cycle. Results: The median LH/FSH ratio for individual subjects did not differ significantly between the PCOS and the non-affected group (1.6 versus 1.2, P=0.14). Only 7.6% of samples from PCOS patients had an LH/FSH ratio above three, compared with 15.6% of samples from normal subjects. Conclusion: This study confirms that measurement of the LH/FSH ratio is of limited use in the diagnosis of PCOS.
AB - Background: The luteinizing hormone/follicle stimulating hormone (LH/FSH) ratio is often requested to help diagnose polycystic ovarian syndrome (PCOS) despite a recent consensus recommending against its use. This study aimed to compare the variability of the LH/FSH ratio in PCOS with that of normal menstruating women over a full cycle in order to establish the diagnostic utility, or otherwise, of the test. Methods: Twelve women with PCOS and 11 matched controls had blood collected at four-day intervals on 10 consecutive occasions over a complete menstrual cycle. Results: The median LH/FSH ratio for individual subjects did not differ significantly between the PCOS and the non-affected group (1.6 versus 1.2, P=0.14). Only 7.6% of samples from PCOS patients had an LH/FSH ratio above three, compared with 15.6% of samples from normal subjects. Conclusion: This study confirms that measurement of the LH/FSH ratio is of limited use in the diagnosis of PCOS.
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U2 - 10.1258/000456306776865188
DO - 10.1258/000456306776865188
M3 - Article
VL - 43
SP - 217
EP - 219
JO - Annals of Clinical Biochemistry
JF - Annals of Clinical Biochemistry
SN - 0004-5632
IS - 3
ER -