The interaction between Comt and Bdnf variants influences obsessive-compulsive-related dysfunctional beliefs

Pino Alonso, Clara López-Solà, Mónica Gratacós, Miquel Angel Fullana, Cinto Segalàs, Eva Real, Narcís Cardoner, Carles Soriano-Mas, Ben J. Harrison, Xavier P. Estivill, José M. Menchón

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Cognitive models emphasize the importance of dysfunctional beliefs as overimportance/need to control thoughts, perfectionism, intolerance of uncertainty, responsibility, and overestimation of threat in obsessive-compulsive disorder (OCD). Twin studies suggest that these beliefs are significantly heritable, but candidate genes associated with them have not been analyzed. We genotyped the Val158Met in the COMT gene and Val66Met variant in the BDNF gene in 141 OCD patients and analyzed their single and interactive effects on the obsessive beliefs questionnaire (OBQ-44). Variability in dysfunctional beliefs was not affected by the COMT or BDNF genotype in isolation, but we detected a significant COMT×. BDNF interaction effect on responsibility/overestimation of threat and overimportance/need to control thoughts scores. Subjects with the BDNF Met-present and the COMT Met-present genotype showed higher scores on responsibility/overestimation of threat. An interaction between dopaminergic and neurotrophic functional gene variants may influence dysfunctional beliefs hypothesized to contribute to the development of OCD.

Original languageEnglish
Pages (from-to)321-327
Number of pages7
JournalJournal of Anxiety Disorders
Volume27
Issue number3
DOIs
Publication statusPublished - 2013
Externally publishedYes

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Brain-Derived Neurotrophic Factor
Obsessive-Compulsive Disorder
Genes
Genotype
Twin Studies
Uncertainty

Keywords

  • BDNF
  • Cognition
  • COMT
  • Dysfunctional beliefs
  • OBQ-44
  • Obsessive-compulsive disorder

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology
  • Medicine(all)

Cite this

Alonso, P., López-Solà, C., Gratacós, M., Fullana, M. A., Segalàs, C., Real, E., ... Menchón, J. M. (2013). The interaction between Comt and Bdnf variants influences obsessive-compulsive-related dysfunctional beliefs. Journal of Anxiety Disorders, 27(3), 321-327. https://doi.org/10.1016/j.janxdis.2013.02.012

The interaction between Comt and Bdnf variants influences obsessive-compulsive-related dysfunctional beliefs. / Alonso, Pino; López-Solà, Clara; Gratacós, Mónica; Fullana, Miquel Angel; Segalàs, Cinto; Real, Eva; Cardoner, Narcís; Soriano-Mas, Carles; Harrison, Ben J.; Estivill, Xavier P.; Menchón, José M.

In: Journal of Anxiety Disorders, Vol. 27, No. 3, 2013, p. 321-327.

Research output: Contribution to journalArticle

Alonso, P, López-Solà, C, Gratacós, M, Fullana, MA, Segalàs, C, Real, E, Cardoner, N, Soriano-Mas, C, Harrison, BJ, Estivill, XP & Menchón, JM 2013, 'The interaction between Comt and Bdnf variants influences obsessive-compulsive-related dysfunctional beliefs', Journal of Anxiety Disorders, vol. 27, no. 3, pp. 321-327. https://doi.org/10.1016/j.janxdis.2013.02.012
Alonso, Pino ; López-Solà, Clara ; Gratacós, Mónica ; Fullana, Miquel Angel ; Segalàs, Cinto ; Real, Eva ; Cardoner, Narcís ; Soriano-Mas, Carles ; Harrison, Ben J. ; Estivill, Xavier P. ; Menchón, José M. / The interaction between Comt and Bdnf variants influences obsessive-compulsive-related dysfunctional beliefs. In: Journal of Anxiety Disorders. 2013 ; Vol. 27, No. 3. pp. 321-327.
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