The ins and outs of tubulin acetylation: More than just a post-translational modification?

Daniel Perdiz, Rafah Mackeh, Christian Poüs, Anita Baillet

Research output: Contribution to journalReview article

142 Citations (Scopus)

Abstract

Microtubules are highly dynamic polymers of α/β tubulin heterodimers that play key roles in cell division and in organizing cell cytoplasm. Although they have been discovered more than two decades ago, tubulin post-translational modifications recently gained a new interest as their role was increasingly highlighted in neuron differentiation and neurodegenerative disorders. Here, we specifically focus on tubulin acetylation from its discovery to recent studies that provide new insights into how it is regulated in health and disease and how it impacts microtubule functions. Even though new mechanisms involving tubulin acetylation are regularly being uncovered, the molecular links between its location inside the microtubule lumen and its regulators and effectors is still poorly understood. This review highlights the emerging roles of tubulin acetylation in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signalling. It also points out that tubulin acetylation should no longer be seen as a passive marker of microtubule stability, but as a broad regulator of microtubule functions.

Original languageEnglish
Pages (from-to)763-771
Number of pages9
JournalCellular Signalling
Volume23
Issue number5
DOIs
Publication statusPublished - 1 May 2011
Externally publishedYes

    Fingerprint

Keywords

  • Acetylation
  • HDAC6
  • Microtubule
  • Post-translational modification
  • Signalling
  • Tubulin

ASJC Scopus subject areas

  • Cell Biology

Cite this