The ins and outs of tubulin acetylation

More than just a post-translational modification?

Daniel Perdiz, Rafah Mackeh, Christian Poüs, Anita Baillet

Research output: Contribution to journalReview article

138 Citations (Scopus)

Abstract

Microtubules are highly dynamic polymers of α/β tubulin heterodimers that play key roles in cell division and in organizing cell cytoplasm. Although they have been discovered more than two decades ago, tubulin post-translational modifications recently gained a new interest as their role was increasingly highlighted in neuron differentiation and neurodegenerative disorders. Here, we specifically focus on tubulin acetylation from its discovery to recent studies that provide new insights into how it is regulated in health and disease and how it impacts microtubule functions. Even though new mechanisms involving tubulin acetylation are regularly being uncovered, the molecular links between its location inside the microtubule lumen and its regulators and effectors is still poorly understood. This review highlights the emerging roles of tubulin acetylation in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signalling. It also points out that tubulin acetylation should no longer be seen as a passive marker of microtubule stability, but as a broad regulator of microtubule functions.

Original languageEnglish
Pages (from-to)763-771
Number of pages9
JournalCellular Signalling
Volume23
Issue number5
DOIs
Publication statusPublished - 1 May 2011
Externally publishedYes

Fingerprint

Post Translational Protein Processing
Tubulin
Acetylation
Microtubules
Neurodegenerative Diseases
Cell Division
Cell Movement
Cell Differentiation
Cell Cycle
Polymers
Cytoplasm
Neurons
Health

Keywords

  • Acetylation
  • HDAC6
  • Microtubule
  • Post-translational modification
  • Signalling
  • Tubulin

ASJC Scopus subject areas

  • Cell Biology

Cite this

The ins and outs of tubulin acetylation : More than just a post-translational modification? / Perdiz, Daniel; Mackeh, Rafah; Poüs, Christian; Baillet, Anita.

In: Cellular Signalling, Vol. 23, No. 5, 01.05.2011, p. 763-771.

Research output: Contribution to journalReview article

Perdiz, Daniel ; Mackeh, Rafah ; Poüs, Christian ; Baillet, Anita. / The ins and outs of tubulin acetylation : More than just a post-translational modification?. In: Cellular Signalling. 2011 ; Vol. 23, No. 5. pp. 763-771.
@article{37b55237bbdf449dbb87cb1abe981491,
title = "The ins and outs of tubulin acetylation: More than just a post-translational modification?",
abstract = "Microtubules are highly dynamic polymers of α/β tubulin heterodimers that play key roles in cell division and in organizing cell cytoplasm. Although they have been discovered more than two decades ago, tubulin post-translational modifications recently gained a new interest as their role was increasingly highlighted in neuron differentiation and neurodegenerative disorders. Here, we specifically focus on tubulin acetylation from its discovery to recent studies that provide new insights into how it is regulated in health and disease and how it impacts microtubule functions. Even though new mechanisms involving tubulin acetylation are regularly being uncovered, the molecular links between its location inside the microtubule lumen and its regulators and effectors is still poorly understood. This review highlights the emerging roles of tubulin acetylation in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signalling. It also points out that tubulin acetylation should no longer be seen as a passive marker of microtubule stability, but as a broad regulator of microtubule functions.",
keywords = "Acetylation, HDAC6, Microtubule, Post-translational modification, Signalling, Tubulin",
author = "Daniel Perdiz and Rafah Mackeh and Christian Po{\"u}s and Anita Baillet",
year = "2011",
month = "5",
day = "1",
doi = "10.1016/j.cellsig.2010.10.014",
language = "English",
volume = "23",
pages = "763--771",
journal = "Cellular Signalling",
issn = "0898-6568",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - The ins and outs of tubulin acetylation

T2 - More than just a post-translational modification?

AU - Perdiz, Daniel

AU - Mackeh, Rafah

AU - Poüs, Christian

AU - Baillet, Anita

PY - 2011/5/1

Y1 - 2011/5/1

N2 - Microtubules are highly dynamic polymers of α/β tubulin heterodimers that play key roles in cell division and in organizing cell cytoplasm. Although they have been discovered more than two decades ago, tubulin post-translational modifications recently gained a new interest as their role was increasingly highlighted in neuron differentiation and neurodegenerative disorders. Here, we specifically focus on tubulin acetylation from its discovery to recent studies that provide new insights into how it is regulated in health and disease and how it impacts microtubule functions. Even though new mechanisms involving tubulin acetylation are regularly being uncovered, the molecular links between its location inside the microtubule lumen and its regulators and effectors is still poorly understood. This review highlights the emerging roles of tubulin acetylation in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signalling. It also points out that tubulin acetylation should no longer be seen as a passive marker of microtubule stability, but as a broad regulator of microtubule functions.

AB - Microtubules are highly dynamic polymers of α/β tubulin heterodimers that play key roles in cell division and in organizing cell cytoplasm. Although they have been discovered more than two decades ago, tubulin post-translational modifications recently gained a new interest as their role was increasingly highlighted in neuron differentiation and neurodegenerative disorders. Here, we specifically focus on tubulin acetylation from its discovery to recent studies that provide new insights into how it is regulated in health and disease and how it impacts microtubule functions. Even though new mechanisms involving tubulin acetylation are regularly being uncovered, the molecular links between its location inside the microtubule lumen and its regulators and effectors is still poorly understood. This review highlights the emerging roles of tubulin acetylation in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signalling. It also points out that tubulin acetylation should no longer be seen as a passive marker of microtubule stability, but as a broad regulator of microtubule functions.

KW - Acetylation

KW - HDAC6

KW - Microtubule

KW - Post-translational modification

KW - Signalling

KW - Tubulin

UR - http://www.scopus.com/inward/record.url?scp=79951855247&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79951855247&partnerID=8YFLogxK

U2 - 10.1016/j.cellsig.2010.10.014

DO - 10.1016/j.cellsig.2010.10.014

M3 - Review article

VL - 23

SP - 763

EP - 771

JO - Cellular Signalling

JF - Cellular Signalling

SN - 0898-6568

IS - 5

ER -