The importance of genetic polymorphisms in renal transplantation

Research output: Contribution to journalShort survey

27 Citations (Scopus)

Abstract

Genetic variations including single nucleotide polymorphisms, dinucleotide repeats and microsatellites have been identified in a number of genes encoding cytokines, cytokine receptors, chemokines and their receptors, adhesion molecules. Several of the polymorphisms are located in the promoter region of the gene, affect transcription or translation, and not infrequently determine the level of expression of the protein product. An interesting and testable hypothesis for the clinical heterogeneity and differential responsiveness in allograft recipients is genetic variation. These nucleotide sequence variations. polymorphisms located in genes contributing to immune repertory and in genes responsible for drug metabolism, are excellent candidates for the differential clinical phenotype. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish
Pages (from-to)71-75
Number of pages5
JournalCurrent Opinion in Urology
Volume10
Issue number2
DOIs
Publication statusPublished - 12 Apr 2000
Externally publishedYes

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ASJC Scopus subject areas

  • Urology

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