The immunologic constant of rejection

Ena Wang, Andrea Worschech, Francesco M. Marincola

Research output: Contribution to journalArticle

102 Citations (Scopus)


The complexity underlying a pathologic process does not necessarily require a complex explanation. The biology determining allograft or cancer rejection, autoimmunity or tissue damage during pathogen infections is complex; however, common patterns are emerging that lead to a common final outcome. For instance, tissue destruction occurs with resolution of the pathogenic process (cancer, infection) or tissue damage and organ failure (autoimmunity, allograft rejection). Observations in humans based on transcriptional profiling converge into what we call an 'immunologic constant of rejection' that characterizes such occurrences. This constant includes the coordinate activation of interferon-stimulated genes (ISGs) and immune effector functions (IEFs). Understanding this final effector pathway may suggest novel strategies for the induction or inhibition of tissue-specific destruction with therapeutic intent in cancer and other immune pathologies.

Original languageEnglish
Pages (from-to)256-262
Number of pages7
JournalTrends in Immunology
Issue number6
Publication statusPublished - Jun 2008
Externally publishedYes


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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