The immunohistochemical localisation of somatostatin receptors 1, 2, 3, and 5 in acoustic neuromas

N. D. Stafford, L. T. Condon, M. J C Rogers, L. Helboe, D. A. Crooks, Stephen Atkin

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Aims: Acoustic neuroma is a benign tumour, which develops through an overproliferation of Schwann cells along the vestibular nerve. Somatostatin is a naturally occurring peptide, which exerts antiproliferative and antiangiogenic effects via five membrane bound receptor subtypes. The aim of this study was to determine whether somatostatin receptor subtypes (SSTRs) 1, 2, 3, and 5 are present inacoustic neuromas. Methods: The expression of SSTRs 1, 2, 3, and 5 was studied in both the Schwann cells and blood vessels of eight acoustic neuroma specimens, by means of immunohistochemistry using novel rabbit polyclonal antibodies raised against human SSTR 1, 2, and 5 subtype specific peptides, and a commercial anti-SSTR3 antibody. Results: SSTR2 was the most prevalent subtype in Schwann cells (seven of eight), with intermediate expression of SSTR3 (six of eight), and lower expression of SSTRs 1 and 5 (four of eight and five of eight, respectively). There was ubiquitous vascular expression of SSTR2, with no evidence of SSTR 1, 3, or 5 expression in blood vessels. Conclusion: SSTRs 1, 2, 3, and 5 are differentially expressed in acoustic neuromas. Somatostatin analogues may have a therapeutic role in the management of this rare and challenging condition.

Original languageEnglish
Pages (from-to)168-171
Number of pages4
JournalJournal of Clinical Pathology
Volume57
Issue number2
DOIs
Publication statusPublished - Feb 2004
Externally publishedYes

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Acoustic Neuroma
Schwann Cells
Blood Vessels
Somatostatin
Vestibular Nerve
Neuroma
Somatostatin Receptors
Peptides
somatostatin receptor type 1
somatostatin receptor 2
Anti-Idiotypic Antibodies
Immunohistochemistry
Rabbits
Membranes
Antibodies
Neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

The immunohistochemical localisation of somatostatin receptors 1, 2, 3, and 5 in acoustic neuromas. / Stafford, N. D.; Condon, L. T.; Rogers, M. J C; Helboe, L.; Crooks, D. A.; Atkin, Stephen.

In: Journal of Clinical Pathology, Vol. 57, No. 2, 02.2004, p. 168-171.

Research output: Contribution to journalArticle

Stafford, N. D. ; Condon, L. T. ; Rogers, M. J C ; Helboe, L. ; Crooks, D. A. ; Atkin, Stephen. / The immunohistochemical localisation of somatostatin receptors 1, 2, 3, and 5 in acoustic neuromas. In: Journal of Clinical Pathology. 2004 ; Vol. 57, No. 2. pp. 168-171.
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