The Immune Basis of Narcolepsy

What Is the Evidence?

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Narcolepsy is a chronic neurologic sleep disorder. Type 1 narcolepsy (narcolepsy-cataplexy) is associated with the destruction of lateral hypothalamic hypocretin neurons. It is thought that the loss of hypocretin neurons is autoimmune mediated. This is because of the close relationship between type 1 narcolepsy and HLA DQB1∗0602 and the onset of narcolepsy at a young age. Evidence suggests that streptococcal and H1N1 influenza infections (and H1N1 vaccination) may be involved in the pathogenesis of narcolepsy. There are suggestions from genetic and immune studies that the immune system plays a key role in narcolepsy.

Original languageEnglish
Pages (from-to)279-287
Number of pages9
JournalSleep Medicine Clinics
Volume12
Issue number3
DOIs
Publication statusPublished - 1 Sep 2017

Fingerprint

Narcolepsy
Cataplexy
Neurons
Nervous System Diseases
Human Influenza
Immune System
Vaccination
Infection

Keywords

  • Autoimmune
  • Human leukocyte antigen
  • Influenza
  • Narcolepsy

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Clinical Psychology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

The Immune Basis of Narcolepsy : What Is the Evidence? / Taheri, Shahrad.

In: Sleep Medicine Clinics, Vol. 12, No. 3, 01.09.2017, p. 279-287.

Research output: Contribution to journalReview article

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