The human leukocyte antigen class i genes in nasopharyngeal carcinoma risk

Elham Hassen, Ghandri Nahla, Noureddine Bouaouina, Lotfi Chouchane

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Nasopharyngeal carcinoma (NPC) is a virally associated cancer which is highly prevalent in Southeast Asia and North Africa. Several linkage analysis studies suggested the association of susceptibility HLA (Human Leukocyte Antigen) alleles and haplotypes with NPC development. The HLA system is very polymorphic and according to the ethnic group studied, it has been found to have the capacity to confer susceptibility or resistance to NPC. Our aim was to review the most important described genetic associations of HLA class I in NPC and to comment on the inconsistent associations found in the different NPC incidence areas. We believe that the mechanisms of these associations may involve HLA genes through the differential capacity of each allele to present antigens. However, because HLA genes contain various linked candidate genes, HLA-NPC associations should be carefully interpreted.

Original languageEnglish
Pages (from-to)119-126
Number of pages8
JournalMolecular Biology Reports
Volume37
Issue number1
DOIs
Publication statusPublished - 1 Jan 2010

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Keywords

  • Genetic associations
  • HLA class I
  • Nasopharyngeal carcinoma

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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