The human glucocorticoid receptor

Molecular basis of biologic function

Nicolas C. Nicolaides, Zoi Galata, Tomoshige Kino, George P. Chrousos, Evangelia Charmandari

Research output: Contribution to journalReview article

240 Citations (Scopus)

Abstract

The characterization of the subfamily of steroid hormone receptors has enhanced our understanding of how a set of hormonally derived lipophilic ligands controls cellular and molecular functions to influence development and help achieve homeostasis. The glucocorticoid receptor (GR), the first member of this subfamily, is a ubiquitously expressed intracellular protein, which functions as a ligand-dependent transcription factor that regulates the expression of glucocorticoid-responsive genes. The effector domains of the GR mediate transcriptional activation by recruiting coregulatory multi-subunit complexes that remodel chromatin, target initiation sites, and stabilize the RNA-polymerase II machinery for repeated rounds of transcription of target genes. This review summarizes the basic aspects of the structure and actions of the human (h) GR, and the molecular basis of its biologic functions.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalSteroids
Volume75
Issue number1
DOIs
Publication statusPublished - Jan 2010
Externally publishedYes

Fingerprint

Glucocorticoid Receptors
Genes
Steroid hormones
Ligands
RNA Polymerase II
Steroid Receptors
Transcription
Transcriptional Activation
Glucocorticoids
Chromatin
Machinery
Homeostasis
Transcription Factors
Chemical activation
Hormones
Proteins

Keywords

  • Generalized glucocorticoid resistance
  • Human glucocorticoid receptor (hGR)
  • Mutations in the hGR gene
  • Polymorphisms of the hGR gene

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Molecular Biology
  • Organic Chemistry
  • Pharmacology

Cite this

Nicolaides, N. C., Galata, Z., Kino, T., Chrousos, G. P., & Charmandari, E. (2010). The human glucocorticoid receptor: Molecular basis of biologic function. Steroids, 75(1), 1-12. https://doi.org/10.1016/j.steroids.2009.09.002

The human glucocorticoid receptor : Molecular basis of biologic function. / Nicolaides, Nicolas C.; Galata, Zoi; Kino, Tomoshige; Chrousos, George P.; Charmandari, Evangelia.

In: Steroids, Vol. 75, No. 1, 01.2010, p. 1-12.

Research output: Contribution to journalReview article

Nicolaides, NC, Galata, Z, Kino, T, Chrousos, GP & Charmandari, E 2010, 'The human glucocorticoid receptor: Molecular basis of biologic function', Steroids, vol. 75, no. 1, pp. 1-12. https://doi.org/10.1016/j.steroids.2009.09.002
Nicolaides, Nicolas C. ; Galata, Zoi ; Kino, Tomoshige ; Chrousos, George P. ; Charmandari, Evangelia. / The human glucocorticoid receptor : Molecular basis of biologic function. In: Steroids. 2010 ; Vol. 75, No. 1. pp. 1-12.
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