The human early-life exposome (HELIX): Project rationale and design

Martine Vrijheid, Rémy Slama, Oliver Robinson, Leda Chatzi, Muireann Coen, Peter van den Hazel, Cathrine Thomsen, John Wright, Toby J. Athersuch, Narcis Avellana, Xavier Basagaña, Celine Brochot, Luca Bucchini, Mariona Bustamante, Angel Carracedo, Maribel Casas, Xavier P. Estivill, Lesley Fairley, Diana van Gent, Juan R. GonzalezBerit Granum, Regina Gražulevičiene, Kristine B. Gutzkow, Jordi Julvez, Hector C. Keun, Manolis Kogevinas, Rosemary R C McEachan, Helle Margrete Meltzer, Eduard Sabidó, Per E. Schwarze, Valérie Siroux, Jordi Sunyer, Elizabeth J. Want, Florence Zeman, Mark J. Nieuwenhuijsen

Research output: Contribution to journalReview article

137 Citations (Scopus)

Abstract

Background: Developmental periods in early life may be particularly vulnerable to impacts of environmental exposures. Human research on this topic has generally focused on single exposure- health effect relationships. The "exposome" concept encompasses the totality of exposures from conception onward, complementing the genome. Objectives: The Human Early-Life Exposome (HELIX) project is a new collaborative research project that aims to implement novel exposure assessment and biomarker methods to characterize early-life exposure to multiple environmental factors and associate these with omics biomarkers and child health outcomes, thus characterizing the "early-life exposome." Here we describe the general design of the project. Methods: In six existing birth cohort studies in Europe, HELIX will estimate prenatal and postnatal exposure to a broad range of chemical and physical exposures. Exposure models will be developed for the full cohorts totaling 32,000 mother-child pairs, and biomarkers will be measured in a subset of 1,200 mother-child pairs. Nested repeat-sampling panel studies (n = 150) will collect data on biomarker variability, use smartphones to assess mobility and physical activity, and perform personal exposure monitoring. Omics techniques will determine molecular profiles (metabolome, proteome, transcriptome, epigenome) associated with exposures. Statistical methods for multiple exposures will provide exposure-response estimates for fetal and child growth, obesity, neurodevelopment, and respiratory outcomes. A health impact assessment exercise will evaluate risks and benefits of combined exposures. Conclusions: HELIX is one of the first attempts to describe the early-life exposome of European populations and unravel its relation to omics markers and health in childhood. As proof of concept, it will form an important first step toward the life-course exposome.

Original languageEnglish
Pages (from-to)535-544
Number of pages10
JournalEnvironmental Health Perspectives
Volume122
Issue number6
DOIs
Publication statusPublished - 2014
Externally publishedYes

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Biomarkers
Health Impact Assessment
Mothers
Exercise
Sampling Studies
Metabolome
Pediatric Obesity
Environmental Exposure
Health
Proteome
Fetal Development
Transcriptome
Research
Cohort Studies
Parturition
Genome
Population

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health
  • Medicine(all)

Cite this

Vrijheid, M., Slama, R., Robinson, O., Chatzi, L., Coen, M., van den Hazel, P., ... Nieuwenhuijsen, M. J. (2014). The human early-life exposome (HELIX): Project rationale and design. Environmental Health Perspectives, 122(6), 535-544. https://doi.org/10.1289/ehp.1307204

The human early-life exposome (HELIX) : Project rationale and design. / Vrijheid, Martine; Slama, Rémy; Robinson, Oliver; Chatzi, Leda; Coen, Muireann; van den Hazel, Peter; Thomsen, Cathrine; Wright, John; Athersuch, Toby J.; Avellana, Narcis; Basagaña, Xavier; Brochot, Celine; Bucchini, Luca; Bustamante, Mariona; Carracedo, Angel; Casas, Maribel; Estivill, Xavier P.; Fairley, Lesley; van Gent, Diana; Gonzalez, Juan R.; Granum, Berit; Gražulevičiene, Regina; Gutzkow, Kristine B.; Julvez, Jordi; Keun, Hector C.; Kogevinas, Manolis; McEachan, Rosemary R C; Meltzer, Helle Margrete; Sabidó, Eduard; Schwarze, Per E.; Siroux, Valérie; Sunyer, Jordi; Want, Elizabeth J.; Zeman, Florence; Nieuwenhuijsen, Mark J.

In: Environmental Health Perspectives, Vol. 122, No. 6, 2014, p. 535-544.

Research output: Contribution to journalReview article

Vrijheid, M, Slama, R, Robinson, O, Chatzi, L, Coen, M, van den Hazel, P, Thomsen, C, Wright, J, Athersuch, TJ, Avellana, N, Basagaña, X, Brochot, C, Bucchini, L, Bustamante, M, Carracedo, A, Casas, M, Estivill, XP, Fairley, L, van Gent, D, Gonzalez, JR, Granum, B, Gražulevičiene, R, Gutzkow, KB, Julvez, J, Keun, HC, Kogevinas, M, McEachan, RRC, Meltzer, HM, Sabidó, E, Schwarze, PE, Siroux, V, Sunyer, J, Want, EJ, Zeman, F & Nieuwenhuijsen, MJ 2014, 'The human early-life exposome (HELIX): Project rationale and design', Environmental Health Perspectives, vol. 122, no. 6, pp. 535-544. https://doi.org/10.1289/ehp.1307204
Vrijheid M, Slama R, Robinson O, Chatzi L, Coen M, van den Hazel P et al. The human early-life exposome (HELIX): Project rationale and design. Environmental Health Perspectives. 2014;122(6):535-544. https://doi.org/10.1289/ehp.1307204
Vrijheid, Martine ; Slama, Rémy ; Robinson, Oliver ; Chatzi, Leda ; Coen, Muireann ; van den Hazel, Peter ; Thomsen, Cathrine ; Wright, John ; Athersuch, Toby J. ; Avellana, Narcis ; Basagaña, Xavier ; Brochot, Celine ; Bucchini, Luca ; Bustamante, Mariona ; Carracedo, Angel ; Casas, Maribel ; Estivill, Xavier P. ; Fairley, Lesley ; van Gent, Diana ; Gonzalez, Juan R. ; Granum, Berit ; Gražulevičiene, Regina ; Gutzkow, Kristine B. ; Julvez, Jordi ; Keun, Hector C. ; Kogevinas, Manolis ; McEachan, Rosemary R C ; Meltzer, Helle Margrete ; Sabidó, Eduard ; Schwarze, Per E. ; Siroux, Valérie ; Sunyer, Jordi ; Want, Elizabeth J. ; Zeman, Florence ; Nieuwenhuijsen, Mark J. / The human early-life exposome (HELIX) : Project rationale and design. In: Environmental Health Perspectives. 2014 ; Vol. 122, No. 6. pp. 535-544.
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abstract = "Background: Developmental periods in early life may be particularly vulnerable to impacts of environmental exposures. Human research on this topic has generally focused on single exposure- health effect relationships. The {"}exposome{"} concept encompasses the totality of exposures from conception onward, complementing the genome. Objectives: The Human Early-Life Exposome (HELIX) project is a new collaborative research project that aims to implement novel exposure assessment and biomarker methods to characterize early-life exposure to multiple environmental factors and associate these with omics biomarkers and child health outcomes, thus characterizing the {"}early-life exposome.{"} Here we describe the general design of the project. Methods: In six existing birth cohort studies in Europe, HELIX will estimate prenatal and postnatal exposure to a broad range of chemical and physical exposures. Exposure models will be developed for the full cohorts totaling 32,000 mother-child pairs, and biomarkers will be measured in a subset of 1,200 mother-child pairs. Nested repeat-sampling panel studies (n = 150) will collect data on biomarker variability, use smartphones to assess mobility and physical activity, and perform personal exposure monitoring. Omics techniques will determine molecular profiles (metabolome, proteome, transcriptome, epigenome) associated with exposures. Statistical methods for multiple exposures will provide exposure-response estimates for fetal and child growth, obesity, neurodevelopment, and respiratory outcomes. A health impact assessment exercise will evaluate risks and benefits of combined exposures. Conclusions: HELIX is one of the first attempts to describe the early-life exposome of European populations and unravel its relation to omics markers and health in childhood. As proof of concept, it will form an important first step toward the life-course exposome.",
author = "Martine Vrijheid and R{\'e}my Slama and Oliver Robinson and Leda Chatzi and Muireann Coen and {van den Hazel}, Peter and Cathrine Thomsen and John Wright and Athersuch, {Toby J.} and Narcis Avellana and Xavier Basaga{\~n}a and Celine Brochot and Luca Bucchini and Mariona Bustamante and Angel Carracedo and Maribel Casas and Estivill, {Xavier P.} and Lesley Fairley and {van Gent}, Diana and Gonzalez, {Juan R.} and Berit Granum and Regina Gražulevičiene and Gutzkow, {Kristine B.} and Jordi Julvez and Keun, {Hector C.} and Manolis Kogevinas and McEachan, {Rosemary R C} and Meltzer, {Helle Margrete} and Eduard Sabid{\'o} and Schwarze, {Per E.} and Val{\'e}rie Siroux and Jordi Sunyer and Want, {Elizabeth J.} and Florence Zeman and Nieuwenhuijsen, {Mark J.}",
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T1 - The human early-life exposome (HELIX)

T2 - Project rationale and design

AU - Vrijheid, Martine

AU - Slama, Rémy

AU - Robinson, Oliver

AU - Chatzi, Leda

AU - Coen, Muireann

AU - van den Hazel, Peter

AU - Thomsen, Cathrine

AU - Wright, John

AU - Athersuch, Toby J.

AU - Avellana, Narcis

AU - Basagaña, Xavier

AU - Brochot, Celine

AU - Bucchini, Luca

AU - Bustamante, Mariona

AU - Carracedo, Angel

AU - Casas, Maribel

AU - Estivill, Xavier P.

AU - Fairley, Lesley

AU - van Gent, Diana

AU - Gonzalez, Juan R.

AU - Granum, Berit

AU - Gražulevičiene, Regina

AU - Gutzkow, Kristine B.

AU - Julvez, Jordi

AU - Keun, Hector C.

AU - Kogevinas, Manolis

AU - McEachan, Rosemary R C

AU - Meltzer, Helle Margrete

AU - Sabidó, Eduard

AU - Schwarze, Per E.

AU - Siroux, Valérie

AU - Sunyer, Jordi

AU - Want, Elizabeth J.

AU - Zeman, Florence

AU - Nieuwenhuijsen, Mark J.

PY - 2014

Y1 - 2014

N2 - Background: Developmental periods in early life may be particularly vulnerable to impacts of environmental exposures. Human research on this topic has generally focused on single exposure- health effect relationships. The "exposome" concept encompasses the totality of exposures from conception onward, complementing the genome. Objectives: The Human Early-Life Exposome (HELIX) project is a new collaborative research project that aims to implement novel exposure assessment and biomarker methods to characterize early-life exposure to multiple environmental factors and associate these with omics biomarkers and child health outcomes, thus characterizing the "early-life exposome." Here we describe the general design of the project. Methods: In six existing birth cohort studies in Europe, HELIX will estimate prenatal and postnatal exposure to a broad range of chemical and physical exposures. Exposure models will be developed for the full cohorts totaling 32,000 mother-child pairs, and biomarkers will be measured in a subset of 1,200 mother-child pairs. Nested repeat-sampling panel studies (n = 150) will collect data on biomarker variability, use smartphones to assess mobility and physical activity, and perform personal exposure monitoring. Omics techniques will determine molecular profiles (metabolome, proteome, transcriptome, epigenome) associated with exposures. Statistical methods for multiple exposures will provide exposure-response estimates for fetal and child growth, obesity, neurodevelopment, and respiratory outcomes. A health impact assessment exercise will evaluate risks and benefits of combined exposures. Conclusions: HELIX is one of the first attempts to describe the early-life exposome of European populations and unravel its relation to omics markers and health in childhood. As proof of concept, it will form an important first step toward the life-course exposome.

AB - Background: Developmental periods in early life may be particularly vulnerable to impacts of environmental exposures. Human research on this topic has generally focused on single exposure- health effect relationships. The "exposome" concept encompasses the totality of exposures from conception onward, complementing the genome. Objectives: The Human Early-Life Exposome (HELIX) project is a new collaborative research project that aims to implement novel exposure assessment and biomarker methods to characterize early-life exposure to multiple environmental factors and associate these with omics biomarkers and child health outcomes, thus characterizing the "early-life exposome." Here we describe the general design of the project. Methods: In six existing birth cohort studies in Europe, HELIX will estimate prenatal and postnatal exposure to a broad range of chemical and physical exposures. Exposure models will be developed for the full cohorts totaling 32,000 mother-child pairs, and biomarkers will be measured in a subset of 1,200 mother-child pairs. Nested repeat-sampling panel studies (n = 150) will collect data on biomarker variability, use smartphones to assess mobility and physical activity, and perform personal exposure monitoring. Omics techniques will determine molecular profiles (metabolome, proteome, transcriptome, epigenome) associated with exposures. Statistical methods for multiple exposures will provide exposure-response estimates for fetal and child growth, obesity, neurodevelopment, and respiratory outcomes. A health impact assessment exercise will evaluate risks and benefits of combined exposures. Conclusions: HELIX is one of the first attempts to describe the early-life exposome of European populations and unravel its relation to omics markers and health in childhood. As proof of concept, it will form an important first step toward the life-course exposome.

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DO - 10.1289/ehp.1307204

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