The human collagenase-3 (CLG3) gene is located on chromosome 11q22.3 clustered to other members of the matrix metalloproteinase gene family

Alberto M. Pendás, Toni Matilla, Xavier P. Estivill, Carlos López-Otín

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Abstract

The gene coding for human collagenase-3 (CLG3), a recently described matrix metalloproteinase produced by breast carcinomas, has been localized by fluorescence in situ hybridization on chromosome 11q22.3. Physical mapping of an isolated YAC clone containing CLG3 has revealed that this gene is tightly linked to those encoding other matrix metalloproteinases, including fibroblast collagenase (CLG1), stromelysin-1 (STMY1), and stromelysin-2 (STMY2). Further mapping of this region using pulsed-field gel electrophoresis has shown that the CLG3 gene is localized to the telomeric side of the matrix metalloproteinase cluster, the relative order of the loci being centromere-STMY2-CLG1-STMY1-CLG3-telomere.

Original languageEnglish
Pages (from-to)615-618
Number of pages4
JournalGenomics
Volume26
Issue number3
DOIs
Publication statusPublished - 10 Apr 1995
Externally publishedYes

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ASJC Scopus subject areas

  • Genetics

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