The human collagenase-3 (CLG3) gene is located on chromosome 11q22.3 clustered to other members of the matrix metalloproteinase gene family

Alberto M. Pendás, Toni Matilla, Xavier P. Estivill, Carlos López-Otín

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

The gene coding for human collagenase-3 (CLG3), a recently described matrix metalloproteinase produced by breast carcinomas, has been localized by fluorescence in situ hybridization on chromosome 11q22.3. Physical mapping of an isolated YAC clone containing CLG3 has revealed that this gene is tightly linked to those encoding other matrix metalloproteinases, including fibroblast collagenase (CLG1), stromelysin-1 (STMY1), and stromelysin-2 (STMY2). Further mapping of this region using pulsed-field gel electrophoresis has shown that the CLG3 gene is localized to the telomeric side of the matrix metalloproteinase cluster, the relative order of the loci being centromere-STMY2-CLG1-STMY1-CLG3-telomere.

Original languageEnglish
Pages (from-to)615-618
Number of pages4
JournalGenomics
Volume26
Issue number3
DOIs
Publication statusPublished - 10 Apr 1995
Externally publishedYes

Fingerprint

Matrix Metalloproteinase 13
Matrix Metalloproteinases
Matrix Metalloproteinase 10
Chromosomes
Matrix Metalloproteinase 3
Genes
Matrix Metalloproteinase 8
Centromere
Pulsed Field Gel Electrophoresis
Telomere
Fluorescence In Situ Hybridization
Clone Cells
Breast Neoplasms

ASJC Scopus subject areas

  • Genetics

Cite this

The human collagenase-3 (CLG3) gene is located on chromosome 11q22.3 clustered to other members of the matrix metalloproteinase gene family. / Pendás, Alberto M.; Matilla, Toni; Estivill, Xavier P.; López-Otín, Carlos.

In: Genomics, Vol. 26, No. 3, 10.04.1995, p. 615-618.

Research output: Contribution to journalArticle

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