The genetics of sleep disorders

Shahrad Taheri, Emmanuel Mignot

Research output: Contribution to journalReview article

85 Citations (Scopus)

Abstract

The contribution of genetic components to the pathology of sleep disorders is increasingly recognised as important. Genetic studies have identified genes that may be important in the regulation of circadian rhythms, which in turn determine the time of sleep onset and waking. Recent studies have shown that mutations in hPER2 are associated with autosomal-dominant familial advanced-sleep-phase syndrome. Genetic studies in a canine model of narcolepsy and in knock-out mice have led to the identification of the hypothalamic hypocretin (orexin) neurotransmitter system as a key target for human narcolepsy. The contribution of genetic factors to obstructive sleep apnoea syndrome (OSAS) has led to a better understanding of this complex disorder that may be part of a larger syndrome associated with respiratory, cardiovascular, and metabolic dysfunction. The aim of this review is to discuss the current knowledge on the role of genetic factors in sleep disorders, in particular circadian disorders, narcolepsy, restless-legs syndrome, and OSAS.

Original languageEnglish
Pages (from-to)242-250
Number of pages9
JournalLancet Neurology
Volume1
Issue number4
DOIs
Publication statusPublished - 1 Apr 2002
Externally publishedYes

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Narcolepsy
Inborn Genetic Diseases
Obstructive Sleep Apnea
Restless Legs Syndrome
Circadian Rhythm
Knockout Mice
Neurotransmitter Agents
Canidae
Sleep
Pathology
Mutation
Genes
Sleep Wake Disorders

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

The genetics of sleep disorders. / Taheri, Shahrad; Mignot, Emmanuel.

In: Lancet Neurology, Vol. 1, No. 4, 01.04.2002, p. 242-250.

Research output: Contribution to journalReview article

Taheri, Shahrad ; Mignot, Emmanuel. / The genetics of sleep disorders. In: Lancet Neurology. 2002 ; Vol. 1, No. 4. pp. 242-250.
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