Abstract
This chapter describes the importance of the fibroblast of the human lung-alveolar structures. The postnatal lung is a complex organ with function to mediate the exchange of oxygen and carbon dioxide between the atmosphere and the blood. The lung brings air and blood into close proximity in structures termed “alveoli.” In the adult human lung, alveoli are comprised of four major cell types. The fibroblast significantly influences alveolar structure and function through its major role in maintaining the interstitial connective tissue. Morphological studies have demonstrated that human fibroblasts are also capable of ingesting collagen fibrils and thus use phagocytotic mechanisms to modulate the connective tissue matrix. Lungs were obtained from human fetuses following abortion and stored briefly in a sterile culture medium until processing could be initiated. After becoming confluent, pulmonary fibroblasts in the tissue culture measure up to 100 μpm in length and 10 pm in maximal width. The chromatin is evenly distributed with only minimal margination.
| Original language | English |
|---|---|
| Pages (from-to) | 37-64 |
| Number of pages | 28 |
| Journal | Methods in Cell Biology |
| Volume | 21 |
| Issue number | C |
| DOIs | |
| Publication status | Published - 1 Jan 1980 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cell Biology
Cite this
The Fibroblast of Human Lung Alveolar Structures : A Differentiated Cell with a Major Role in Lung Structure and Function. / Bradley, Kathryn H.; Kawanami, Oichi; Ferrans, Victor J.; Crystal, Ronald.
In: Methods in Cell Biology, Vol. 21, No. C, 01.01.1980, p. 37-64.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The Fibroblast of Human Lung Alveolar Structures
T2 - A Differentiated Cell with a Major Role in Lung Structure and Function
AU - Bradley, Kathryn H.
AU - Kawanami, Oichi
AU - Ferrans, Victor J.
AU - Crystal, Ronald
PY - 1980/1/1
Y1 - 1980/1/1
N2 - This chapter describes the importance of the fibroblast of the human lung-alveolar structures. The postnatal lung is a complex organ with function to mediate the exchange of oxygen and carbon dioxide between the atmosphere and the blood. The lung brings air and blood into close proximity in structures termed “alveoli.” In the adult human lung, alveoli are comprised of four major cell types. The fibroblast significantly influences alveolar structure and function through its major role in maintaining the interstitial connective tissue. Morphological studies have demonstrated that human fibroblasts are also capable of ingesting collagen fibrils and thus use phagocytotic mechanisms to modulate the connective tissue matrix. Lungs were obtained from human fetuses following abortion and stored briefly in a sterile culture medium until processing could be initiated. After becoming confluent, pulmonary fibroblasts in the tissue culture measure up to 100 μpm in length and 10 pm in maximal width. The chromatin is evenly distributed with only minimal margination.
AB - This chapter describes the importance of the fibroblast of the human lung-alveolar structures. The postnatal lung is a complex organ with function to mediate the exchange of oxygen and carbon dioxide between the atmosphere and the blood. The lung brings air and blood into close proximity in structures termed “alveoli.” In the adult human lung, alveoli are comprised of four major cell types. The fibroblast significantly influences alveolar structure and function through its major role in maintaining the interstitial connective tissue. Morphological studies have demonstrated that human fibroblasts are also capable of ingesting collagen fibrils and thus use phagocytotic mechanisms to modulate the connective tissue matrix. Lungs were obtained from human fetuses following abortion and stored briefly in a sterile culture medium until processing could be initiated. After becoming confluent, pulmonary fibroblasts in the tissue culture measure up to 100 μpm in length and 10 pm in maximal width. The chromatin is evenly distributed with only minimal margination.
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U2 - 10.1016/S0091-679X(08)60757-8
DO - 10.1016/S0091-679X(08)60757-8
M3 - Article
VL - 21
SP - 37
EP - 64
JO - Methods in Cell Biology
JF - Methods in Cell Biology
SN - 0091-679X
IS - C
ER -