The emerging role of epigenetics in cardiovascular disease

Research output: Contribution to journalReview article

43 Citations (Scopus)

Abstract

There is a worldwide epidemic of cardiovascular diseases causing not only a public health issue but also accounting for trillions of dollars of healthcare expenditure. Studies pertaining to epidemiology, pathophysiology, molecular biology, gene identification and genetic linkage maps have been able to lay a strong foundation for both the diagnosis and treatment of cardiovascular medicine. Although the concept of ‘epigenetics’ is not recent, the term in current usage is extended from the initial concept of ‘controlling developmental gene expression and signaling pathways in undifferentiated zygotes’ to include heritable changes to gene expression that are not from differences in the genetic code. The impact of epigenetics in cardiovascular disease is now emerging as an important regulatory key player at different levels from pathophysiology to therapeutics. This review focuses on the emerging role of epigenetics in major cardiovascular medicine specialties such as coronary artery disease, heart failure, cardiac hypertrophy and diabetes.

Original languageEnglish
Pages (from-to)178-187
Number of pages10
JournalTherapeutic Advances in Chronic Disease
Volume5
Issue number4
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Epigenomics
Cardiovascular Diseases
Medicine
Genetic Code
Developmental Genes
Gene Expression
Genetic Linkage
Zygote
Cardiomegaly
Health Expenditures
Coronary Artery Disease
Molecular Biology
Epidemiology
Heart Failure
Public Health
Delivery of Health Care
Genes
Therapeutics

Keywords

  • Cardiac hypertrophy
  • Cardiology
  • Cardiovascular disease
  • Coronary artery disease
  • Diabetes
  • Epigenetics
  • Heart failure

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

The emerging role of epigenetics in cardiovascular disease. / Abi Khalil, Charbel.

In: Therapeutic Advances in Chronic Disease, Vol. 5, No. 4, 2014, p. 178-187.

Research output: Contribution to journalReview article

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