The effects of thermally-induced activity in vivo upon the ultrastructure and Na, K and Cl composition of the epithelial cells of sweat glands from patients with cystic fibrosis

S. M. Wilson, H. Y. Elder, Ann M. Sutton, D. Mc Ewan Jenkinson, F. Cockburn, I. Montgomery, S. A. McWilliams, Douglas Bovell

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The secretory cells of the fundus of sweat glands from cystic fibrosis (CF) patients had higher Na and Cl contents and showed more granule depletion, cellular disruption and dilated intercellular canaliculi than normal. The cells of the coiled duct also had higher cytoplasmic levels of Na and Cl but were structurally normal. Thermal stimulation produced ultrastructural changes in the CF fundus comparable to normal, including further dilatation of the basolateral clefts, but did not induce the marked changes in the coiled duct which normally occur. The elevated Na and fall in K in the fundus and raised Na and Cl in the coiled duct upon activation, were not observed in the CF glands in which no significant changes were detected.

Original languageEnglish
Pages (from-to)691-700
Number of pages10
JournalTissue and Cell
Volume20
Issue number5
DOIs
Publication statusPublished - 1988
Externally publishedYes

Fingerprint

Sweat Glands
Cystic Fibrosis
Epithelial Cells
Dilatation
Hot Temperature

Keywords

  • cystic fibrosis
  • Sweat glands
  • ultrastructure
  • X-ray microanalysis

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

The effects of thermally-induced activity in vivo upon the ultrastructure and Na, K and Cl composition of the epithelial cells of sweat glands from patients with cystic fibrosis. / Wilson, S. M.; Elder, H. Y.; Sutton, Ann M.; Jenkinson, D. Mc Ewan; Cockburn, F.; Montgomery, I.; McWilliams, S. A.; Bovell, Douglas.

In: Tissue and Cell, Vol. 20, No. 5, 1988, p. 691-700.

Research output: Contribution to journalArticle

Wilson, S. M. ; Elder, H. Y. ; Sutton, Ann M. ; Jenkinson, D. Mc Ewan ; Cockburn, F. ; Montgomery, I. ; McWilliams, S. A. ; Bovell, Douglas. / The effects of thermally-induced activity in vivo upon the ultrastructure and Na, K and Cl composition of the epithelial cells of sweat glands from patients with cystic fibrosis. In: Tissue and Cell. 1988 ; Vol. 20, No. 5. pp. 691-700.
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AU - Jenkinson, D. Mc Ewan

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AU - Montgomery, I.

AU - McWilliams, S. A.

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