The effect of indomethacin on the duration of the hypotensive action of bradykinin in Dahl salt-resistant rats

Role of cyclooxygenase inhibition

J. N. Sharma, P. G. Fernandez, Christopher Triggle

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The Dahl salt resistant (DR) rat maintained on a low, 0.4%, or a high 8.0% salt-diet remained normotensive. The bradykinin (BK) induced falls in the systolic (SBP) and diastolic (DBP) were unaffected (P > 0.05) by the presence of indomethacin (5 mg/kg). Indomethacin, however, caused a substantial (P < 0.001) reduction in the duration of the hypotensive action of bradykinin. It is speculated that the indomethacin effects result from an inhibition of the cyclooxygenase system in DR rats.

Original languageEnglish
Pages (from-to)131-135
Number of pages5
JournalProstaglandins, Leukotrienes and Medicine
Volume14
Issue number1
DOIs
Publication statusPublished - 1984
Externally publishedYes

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Inbred Dahl Rats
Bradykinin
Prostaglandin-Endoperoxide Synthases
Indomethacin
Rats
Salts
Nutrition
Diet

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology

Cite this

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abstract = "The Dahl salt resistant (DR) rat maintained on a low, 0.4{\%}, or a high 8.0{\%} salt-diet remained normotensive. The bradykinin (BK) induced falls in the systolic (SBP) and diastolic (DBP) were unaffected (P > 0.05) by the presence of indomethacin (5 mg/kg). Indomethacin, however, caused a substantial (P < 0.001) reduction in the duration of the hypotensive action of bradykinin. It is speculated that the indomethacin effects result from an inhibition of the cyclooxygenase system in DR rats.",
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T1 - The effect of indomethacin on the duration of the hypotensive action of bradykinin in Dahl salt-resistant rats

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AU - Fernandez, P. G.

AU - Triggle, Christopher

PY - 1984

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AB - The Dahl salt resistant (DR) rat maintained on a low, 0.4%, or a high 8.0% salt-diet remained normotensive. The bradykinin (BK) induced falls in the systolic (SBP) and diastolic (DBP) were unaffected (P > 0.05) by the presence of indomethacin (5 mg/kg). Indomethacin, however, caused a substantial (P < 0.001) reduction in the duration of the hypotensive action of bradykinin. It is speculated that the indomethacin effects result from an inhibition of the cyclooxygenase system in DR rats.

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