The early antitumor immune response is necessary for tumor growth: Re-visiting prehn's hypothesis in the human melanoma system

Giorgio Parmiani, Cristina Maccalli

Research output: Contribution to journalArticle

4 Citations (Scopus)


Early events responsible of tumor growth in patients with a normal immune system are poorly understood. Here, we discuss, in the context of human melanoma, the Prehn hypothesis according to which a weak antitumor immune response may be required for tumor growth before weakly or nonimmunogenic tumor cell subpopulations are selected by the immune system.

Original languageEnglish
Pages (from-to)930-934
Number of pages5
Issue number6
Publication statusPublished - 1 Dec 2012



  • Cancer immunosurveillance
  • Early tumor growth
  • Immune escape
  • Melanoma
  • Microenvironment
  • Tumor antigens

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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