The dual role of IL-10

Simone Mocellin, Monica C. Panelli, Ena Wang, Dirk Nagorsen, Francesco M. Marincola

Research output: Contribution to journalReview article

332 Citations (Scopus)

Abstract

Classification of cytokines as pro- versus anti-inflammatory might not apply to the pleiotropic effects of interleukin-10 (IL-10). Several reports suggest that IL-10 enhances the function of natural killer cells, which leads, through pathogen destruction, to increased antigen availability. In addition, by inhibiting the maturation of antigen-presenting cells (APCs), IL-10 preserves their ability for antigen uptake while simultaneously hampering their migration to draining lymph nodes. This review suggests that this 'antigen-loading' phase might constitute an important component of the innate immune reaction to a pathogen. Additional proinflammatory stimuli might subsequently lead to maturation of 'loaded' APCs that could migrate to draining lymph nodes or recruit and activate adaptive immune effectors locally.

Original languageEnglish
Pages (from-to)36-43
Number of pages8
JournalTrends in Immunology
Volume24
Issue number1
DOIs
Publication statusPublished - 1 Jan 2003
Externally publishedYes

Fingerprint

Interleukin-10
Antigen-Presenting Cells
Antigens
Lymph Nodes
Natural Killer Cells
Anti-Inflammatory Agents
Cytokines

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Mocellin, S., Panelli, M. C., Wang, E., Nagorsen, D., & Marincola, F. M. (2003). The dual role of IL-10. Trends in Immunology, 24(1), 36-43. https://doi.org/10.1016/S1471-4906(02)00009-1

The dual role of IL-10. / Mocellin, Simone; Panelli, Monica C.; Wang, Ena; Nagorsen, Dirk; Marincola, Francesco M.

In: Trends in Immunology, Vol. 24, No. 1, 01.01.2003, p. 36-43.

Research output: Contribution to journalReview article

Mocellin, S, Panelli, MC, Wang, E, Nagorsen, D & Marincola, FM 2003, 'The dual role of IL-10', Trends in Immunology, vol. 24, no. 1, pp. 36-43. https://doi.org/10.1016/S1471-4906(02)00009-1
Mocellin S, Panelli MC, Wang E, Nagorsen D, Marincola FM. The dual role of IL-10. Trends in Immunology. 2003 Jan 1;24(1):36-43. https://doi.org/10.1016/S1471-4906(02)00009-1
Mocellin, Simone ; Panelli, Monica C. ; Wang, Ena ; Nagorsen, Dirk ; Marincola, Francesco M. / The dual role of IL-10. In: Trends in Immunology. 2003 ; Vol. 24, No. 1. pp. 36-43.
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