The dual role of IL-10

Simone Mocellin, Monica C. Panelli, Ena Wang, Dirk Nagorsen, Francesco M. Marincola

Research output: Contribution to journalReview article

340 Citations (Scopus)


Classification of cytokines as pro- versus anti-inflammatory might not apply to the pleiotropic effects of interleukin-10 (IL-10). Several reports suggest that IL-10 enhances the function of natural killer cells, which leads, through pathogen destruction, to increased antigen availability. In addition, by inhibiting the maturation of antigen-presenting cells (APCs), IL-10 preserves their ability for antigen uptake while simultaneously hampering their migration to draining lymph nodes. This review suggests that this 'antigen-loading' phase might constitute an important component of the innate immune reaction to a pathogen. Additional proinflammatory stimuli might subsequently lead to maturation of 'loaded' APCs that could migrate to draining lymph nodes or recruit and activate adaptive immune effectors locally.

Original languageEnglish
Pages (from-to)36-43
Number of pages8
JournalTrends in Immunology
Issue number1
Publication statusPublished - 1 Jan 2003


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Mocellin, S., Panelli, M. C., Wang, E., Nagorsen, D., & Marincola, F. M. (2003). The dual role of IL-10. Trends in Immunology, 24(1), 36-43.