The cytokine network in women with an asymptomatic short cervix and the risk of preterm delivery

Adi L. Tarca, Wendy Fitzgerald, Piya Chaemsaithong, Zhonghui Xu, Sonia S. Hassan, Jean-Charles B. Grivel, Nardhy Gomez-Lopez, Bogdan Panaitescu, Percy Pacora, Eli Maymon, Offer Erez, Leonid Margolis, Roberto Romero

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10 Citations (Scopus)


Problem: To characterize the amniotic fluid (AF) inflammatory-related protein (IRP) network in patients with a sonographic short cervix (SCx) and to determine its relation to early preterm delivery (ePTD). Method of study: A retrospective cohort study included women with a SCx (≤25 mm; n=223) who had amniocentesis and were classified according to gestational age (GA) at diagnosis and delivery (ePTD <32 weeks of gestation). Results: (i) In women with a SCx ≤ 22 1/7 weeks, the concentration of most IRPs increased as the cervix shortened; those with ePTD had a higher rate of increase in MIP-1α, MCP-1, and IL-6 concentrations than those delivering later; and (ii) the concentration of most IRPs and the correlation between several IRP pairs were higher in the ePTD group than for those delivering later. Conclusion: Women with a SCx at 16-22 1/7 weeks have a unique AF cytokine network that correlates with cervical length at diagnosis and GA at delivery. This network may aid in predicting ePTD.

Original languageEnglish
Article numbere12686
JournalAmerican Journal of Reproductive Immunology
Issue number3
Publication statusPublished - 1 Sep 2017



  • amniocentesis
  • cervical insufficiency
  • cytokine
  • macrophage inflammatory protein
  • network analysis
  • preterm birth

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Tarca, A. L., Fitzgerald, W., Chaemsaithong, P., Xu, Z., Hassan, S. S., Grivel, J-C. B., Gomez-Lopez, N., Panaitescu, B., Pacora, P., Maymon, E., Erez, O., Margolis, L., & Romero, R. (2017). The cytokine network in women with an asymptomatic short cervix and the risk of preterm delivery. American Journal of Reproductive Immunology, 78(3), [e12686].