THE CONTROL OF POTASSIUM (86Rb+) EFFLUX IN THE ISOLATED HUMAN SWEAT GLAND

Douglas L. Bovell, Hugh Y. Elder, David Mc Ewan Jenkinson, Stuart M. Wilson

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Abstract

Sweat glands, isolated from strips of human skin and pre‐loaded with 86Rb+, a marker of potassium transport, were superfused with physiological saline and rate constants for 86Rb+ efflux calculated. The rate of efflux during superfusion with Ca2+−free saline was lower than that measured in the presence of calcium (2·56 mM). Acetylcholine increased the rate of 86Rb+ efflux and this response could be resolved into two components: an initial transient phase which was Ca2+−independent and a slowly declining Ca2+−dependent phase. Adrenaline only caused a Ca2+−dependent increase in efflux. It is suggested that the potassium permeability of the secretory cells increases during activity.

Original languageEnglish
Pages (from-to)267-276
Number of pages10
JournalQuarterly Journal of Experimental Physiology
Volume74
Issue number3
DOIs
Publication statusPublished - 16 May 1989

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ASJC Scopus subject areas

  • Physiology

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