Sweat glands, isolated from strips of human skin and pre‐loaded with 86Rb+, a marker of potassium transport, were superfused with physiological saline and rate constants for 86Rb+ efflux calculated. The rate of efflux during superfusion with Ca2+−free saline was lower than that measured in the presence of calcium (2·56 mM). Acetylcholine increased the rate of 86Rb+ efflux and this response could be resolved into two components: an initial transient phase which was Ca2+−independent and a slowly declining Ca2+−dependent phase. Adrenaline only caused a Ca2+−dependent increase in efflux. It is suggested that the potassium permeability of the secretory cells increases during activity.
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