L'apport de l'approche immunoprotéomique SERPA dans les cancers mammaires

Translated title of the contribution: The contribution of the immunoproteomic approach SERPA in breast cancers

B. Hamrita, H. Ben Nasr, K. Chahed, L. Chouchane

Research output: Contribution to journalShort survey

Abstract

Breast cancer is the leading cause of female mortality. It is defined as an abnormal and uncontrolled proliferation of certain cells. The expression of many proteins is altered in the cancerous transformation and in tumor progression. This protein expression can trigger a response of auto-immunity and the release of autoantibodies that seem to have a crucial role in the prognosis, diagnosis and for the creation of new potential therapeutic targets. Today, the immunoproteomic approach Serological Proteomic Analysis (SERPA) allows simultaneous search of autoantibodies and identification of immunodominant antigenic proteins. This technique has the huge advantage of being rapid and specific. In this review, we have focused the contribution of this immunoproteomic approach to the breast cancer, and the discovery of new markers for diagnosis and prognosis.

Original languageFrench
Pages (from-to)140-146
Number of pages7
JournalImmuno-Analyse et Biologie Specialisee
Volume25
Issue number3
DOIs
Publication statusPublished - 1 Jun 2010

    Fingerprint

Keywords

  • Autoantibodies
  • Breast cancer
  • Proteins markers
  • Proteomic
  • SERPA

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this