The Continuum of Cancer Immunosurveillance: Prognostic, Predictive, and Mechanistic Signatures

Jérôme Galon, Helen K. Angell, Davide Bedognetti, Francesco M. Marincola

Research output: Contribution to journalReview article

367 Citations (Scopus)

Abstract

Numerous analyses of large patient cohorts identified specific patterns of immune activation associated with patient survival. We established these as the immune contexture, encompassing the type, functional orientation, density, and location of adaptive immune cells within distinct tumor regions. Based on the immune contexture, a standardized, powerful immune stratification system, the Immunoscore, was delineated. The immune contexture is characterized by immune signatures also observed in association with the broader phenomenon of immune-mediated, tissue-specific destruction. We defined these as the immunologic constant of rejection. Predictive, prognostic, and mechanistic immune signatures overlap, and a continuum of intratumor immune reactions exists. The balance between tumor cell growth and elimination may be tippedupon a crescendo induced by immune manipulations aimed at enhancing naturally occurring immunosurveillance. Here, we propose a broader immunological interpretation of these three concepts-immune contexture, Immunoscore, and immunologic constant of rejection-that segregates oncogenic processes independently of their tissue origin.

Original languageEnglish
Pages (from-to)11-26
Number of pages16
JournalImmunity
Volume39
Issue number1
DOIs
Publication statusPublished - 25 Jul 2013
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this