The cholinergic regulation of potassium (86Rb+) permeability in sweat glands isolated from patients with cystic fibrosis

SM Wilson, JD Pediani, F. Cockburn, Douglas Bovell, DM Jenkinson, JY Paton, J. Coutts, R. Davidson, J. Lambert, G. Morris, al et

Research output: Contribution to journalArticle

Abstract

Sweat glands isolated from skin obtained from normal subjects and patients with cystic fibrosis (CF) were pre‐loaded with 86Rb+ and superfused with a physiological salt solution and the rate of 86Rb+ efflux was measured as an indicator of cellular potassium permeability. Acetylcholine always evoked a permeability increase in the glands from control subjects and this response could be resolved into calcium‐dependent and calcium‐independent components. Sweat glands from CF patients did not show such consistent responses. In three individuals the glands were abnormally insensitive to acetylcholine but normal responsiveness was seen in a fourth case. It is proposed that CF can induce dysfunction of calcium‐dependent control processes in sweat glands.

Original languageEnglish
Pages (from-to)573-578
Number of pages6
JournalExperimental Physiology
Volume76
Issue number4
DOIs
Publication statusPublished - 1 Jul 1991
Externally publishedYes

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Sweat Glands
Cystic Fibrosis
Cholinergic Agents
Permeability
Potassium
Acetylcholine
Salts
Skin

ASJC Scopus subject areas

  • Physiology

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The cholinergic regulation of potassium (86Rb+) permeability in sweat glands isolated from patients with cystic fibrosis. / Wilson, SM; Pediani, JD; Cockburn, F.; Bovell, Douglas; Jenkinson, DM; Paton, JY; Coutts, J.; Davidson, R.; Lambert, J.; Morris, G.; et, al.

In: Experimental Physiology, Vol. 76, No. 4, 01.07.1991, p. 573-578.

Research output: Contribution to journalArticle

Wilson, SM, Pediani, JD, Cockburn, F, Bovell, D, Jenkinson, DM, Paton, JY, Coutts, J, Davidson, R, Lambert, J, Morris, G & et, A 1991, 'The cholinergic regulation of potassium (86Rb+) permeability in sweat glands isolated from patients with cystic fibrosis', Experimental Physiology, vol. 76, no. 4, pp. 573-578. https://doi.org/10.1113/expphysiol.1991.sp003524
Wilson, SM ; Pediani, JD ; Cockburn, F. ; Bovell, Douglas ; Jenkinson, DM ; Paton, JY ; Coutts, J. ; Davidson, R. ; Lambert, J. ; Morris, G. ; et, al. / The cholinergic regulation of potassium (86Rb+) permeability in sweat glands isolated from patients with cystic fibrosis. In: Experimental Physiology. 1991 ; Vol. 76, No. 4. pp. 573-578.
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