The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts

Ian T. Paulsen, Rekha Seshadri, Karen E. Nelson, Jonathan A. Eisen, John F. Heidelberg, Timothy D. Read, Robert J. Dodson, Lowell Umayam, Lauren M. Brinkac, Maureen J. Beanan, Sean C. Daugherty, Robert T. Deboy, A. Scott Durkin, James F. Kolonay, Ramana Madupu, William C. Nelson, Bola Ayodeji, Margaret Kraul, Jyoti Shetty, Joel Malek & 11 others Susan E. Van Aken, Steven Riedmuller, Herve Tettelin, Steven R. Gill, Owen White, Steven L. Salzberg, David L. Hoover, Luther E. Lindler, Shirley M. Halling, Stephen M. Boyle, Claire M. Fraser

Research output: Contribution to journalArticle

331 Citations (Scopus)

Abstract

The 3.31-Mb genome sequence of the intracellular pathogen and potential bioterrorism agent, Brucella suis, was determined. Comparison of B. suis with Brucella melitensis has defined a finite set of differences that could be responsible for the differences in virulence and host preference between these organisms, and indicates that phage have played a significant role in their divergence. Analysis of the B. suis genome reveals transport and metabolic capabilities akin to soil/plant-associated bacteria. Extensive gene synteny between B. suis chromosome 1 and the genome of the plant symbiont Mesorhizobium loti emphasizes the similarity between this animal pathogen and plant pathogens and symbionts. A limited repertoire of genes homologous to known bacterial virulence factors were identified.

Original languageEnglish
Pages (from-to)13148-13153
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume99
Issue number20
DOIs
Publication statusPublished - 1 Oct 2002
Externally publishedYes

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Brucella suis
Genome
Mesorhizobium
Biological Warfare Agents
Brucella melitensis
Synteny
Plant Genome
Chromosomes, Human, Pair 1
Virulence Factors
Bacteriophages
Genes
Virulence
Soil
Bacteria

ASJC Scopus subject areas

  • General

Cite this

The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts. / Paulsen, Ian T.; Seshadri, Rekha; Nelson, Karen E.; Eisen, Jonathan A.; Heidelberg, John F.; Read, Timothy D.; Dodson, Robert J.; Umayam, Lowell; Brinkac, Lauren M.; Beanan, Maureen J.; Daugherty, Sean C.; Deboy, Robert T.; Durkin, A. Scott; Kolonay, James F.; Madupu, Ramana; Nelson, William C.; Ayodeji, Bola; Kraul, Margaret; Shetty, Jyoti; Malek, Joel; Van Aken, Susan E.; Riedmuller, Steven; Tettelin, Herve; Gill, Steven R.; White, Owen; Salzberg, Steven L.; Hoover, David L.; Lindler, Luther E.; Halling, Shirley M.; Boyle, Stephen M.; Fraser, Claire M.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, No. 20, 01.10.2002, p. 13148-13153.

Research output: Contribution to journalArticle

Paulsen, IT, Seshadri, R, Nelson, KE, Eisen, JA, Heidelberg, JF, Read, TD, Dodson, RJ, Umayam, L, Brinkac, LM, Beanan, MJ, Daugherty, SC, Deboy, RT, Durkin, AS, Kolonay, JF, Madupu, R, Nelson, WC, Ayodeji, B, Kraul, M, Shetty, J, Malek, J, Van Aken, SE, Riedmuller, S, Tettelin, H, Gill, SR, White, O, Salzberg, SL, Hoover, DL, Lindler, LE, Halling, SM, Boyle, SM & Fraser, CM 2002, 'The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts', Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 20, pp. 13148-13153. https://doi.org/10.1073/pnas.192319099
Paulsen, Ian T. ; Seshadri, Rekha ; Nelson, Karen E. ; Eisen, Jonathan A. ; Heidelberg, John F. ; Read, Timothy D. ; Dodson, Robert J. ; Umayam, Lowell ; Brinkac, Lauren M. ; Beanan, Maureen J. ; Daugherty, Sean C. ; Deboy, Robert T. ; Durkin, A. Scott ; Kolonay, James F. ; Madupu, Ramana ; Nelson, William C. ; Ayodeji, Bola ; Kraul, Margaret ; Shetty, Jyoti ; Malek, Joel ; Van Aken, Susan E. ; Riedmuller, Steven ; Tettelin, Herve ; Gill, Steven R. ; White, Owen ; Salzberg, Steven L. ; Hoover, David L. ; Lindler, Luther E. ; Halling, Shirley M. ; Boyle, Stephen M. ; Fraser, Claire M. / The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts. In: Proceedings of the National Academy of Sciences of the United States of America. 2002 ; Vol. 99, No. 20. pp. 13148-13153.
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