The association of Epstein-Barr virus with smooth-muscle tumors occurring after organ transplantation

Elsie S. Lee, Joseph Locker, Michael Nalesnik, Jorge Reyes, Ronald Jaffe, Mouied Alashari, Bakr Nour, Bakr Nour, Paul S. Dickman

Research output: Contribution to journalArticle

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Abstract

Background. Epstein-Barr virus (EBV) has been associated with nasopharyngeal carcinoma, some lymphomas, and lymphoproliferative disease after organ transplantation. Many lymphoproliferative tumors that occur after transplantation are clonal, a property that classifies them as neoplastic. Clonality can be determined by analysis of the extrachromosomal circular DNA episomes produced by EBV infection. Methods. We describe three young children in whom smooth-muscle tumors developed 18 months to 5 1/2 years after liver transplantation with immunosuppression. We examined the tumors by microscopy and with immunohistochemical studies and molecular genetic analyses of the EBV DNA. Results. The tumors were composed of spindle cells with smooth- muscle features and resembled those described in patients with the acquired immunodeficiency syndrome. Immunohistochemical analysis was negative for EBV latent membrane protein and EBV receptor (cd21), but positive for EBV nuclear antigen 2. In situ hybridization revealed nuclear EBV sequences, and molecular genetic analysis showed the EBV genome to be clonal in all three patients. Conclusions. Smooth-muscle tumors that developed after organ transplantation contained clonal EBV, suggesting that the virus has a role in the development of these neoplastic lesions.

Original languageEnglish
Pages (from-to)19-25
Number of pages7
JournalNew England Journal of Medicine
Volume332
Issue number1
DOIs
Publication statusPublished - 5 Jan 1995
Externally publishedYes

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Smooth Muscle Tumor
Organ Transplantation
Human Herpesvirus 4
Molecular Biology
Complement 3d Receptors
Epstein-Barr Virus Nuclear Antigens
Circular DNA
Neoplasms
Epstein-Barr Virus Infections
Liver Transplantation
Immunosuppression
Smooth Muscle Myocytes
In Situ Hybridization
Microscopy
Lymphoma
Membrane Proteins
Acquired Immunodeficiency Syndrome
Plasmids
Transplantation
Genome

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lee, E. S., Locker, J., Nalesnik, M., Reyes, J., Jaffe, R., Alashari, M., ... Dickman, P. S. (1995). The association of Epstein-Barr virus with smooth-muscle tumors occurring after organ transplantation. New England Journal of Medicine, 332(1), 19-25. https://doi.org/10.1056/NEJM199501053320104

The association of Epstein-Barr virus with smooth-muscle tumors occurring after organ transplantation. / Lee, Elsie S.; Locker, Joseph; Nalesnik, Michael; Reyes, Jorge; Jaffe, Ronald; Alashari, Mouied; Nour, Bakr; Nour, Bakr; Dickman, Paul S.

In: New England Journal of Medicine, Vol. 332, No. 1, 05.01.1995, p. 19-25.

Research output: Contribution to journalArticle

Lee, ES, Locker, J, Nalesnik, M, Reyes, J, Jaffe, R, Alashari, M, Nour, B, Nour, B & Dickman, PS 1995, 'The association of Epstein-Barr virus with smooth-muscle tumors occurring after organ transplantation', New England Journal of Medicine, vol. 332, no. 1, pp. 19-25. https://doi.org/10.1056/NEJM199501053320104
Lee, Elsie S. ; Locker, Joseph ; Nalesnik, Michael ; Reyes, Jorge ; Jaffe, Ronald ; Alashari, Mouied ; Nour, Bakr ; Nour, Bakr ; Dickman, Paul S. / The association of Epstein-Barr virus with smooth-muscle tumors occurring after organ transplantation. In: New England Journal of Medicine. 1995 ; Vol. 332, No. 1. pp. 19-25.
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