The association of CD81 polymorphisms with alloimmunization in sickle cell disease

Zohreh Tatari Calderone, Ryad Tamouza, Gama P. Le Bouder, Ramita Dewan, Naomi L C Luban, Jacqueline Lasserre, Jacqueline Maury, François Lionnet, Rajagopal Krishnamoorthy, Robert Girot, Stanislav Vukmanovic

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The goal of the present work was to identify the candidate genetic markers predictive of alloimmunization in sickle cell disease (SCD). Red blood cell (RBC) transfusion is indicated for acute treatment, prevention, and abrogation of some complications of SCD. A well-known consequence of multiple RBC transfusions is alloimmunization. Given that a subset of SCD patients develop multiple RBC allo-/autoantibodies, while others do not in a similar multiple transfusional setting, we investigated a possible genetic basis for alloimmunization. Biomarker(s) which predicts (predict) susceptibility to alloimmunization could identify patients at risk before the onset of a transfusion program and thus may have important implications for clinical management. In addition, such markers could shed light on the mechanism(s) underlying alloimmunization. We genotyped 27 single nucleotide polymorphisms (SNPs) in the CD81, CHRNA10, and ARHG genes in two groups of SCD patients. One group (35) of patients developed alloantibodies, and another (40) had no alloantibodies despite having received multiple transfusions. Two SNPs in the CD81 gene, that encodes molecule involved in the signal modulation of B lymphocytes, show a strong association with alloimmunization. If confirmed in prospective studies with larger cohorts, the two SNPs identified in this retrospective study could serve as predictive biomarkers for alloimmunization.

Original languageEnglish
Article number937846
JournalClinical and Developmental Immunology
Volume2013
DOIs
Publication statusPublished - 2013
Externally publishedYes

Fingerprint

Sickle Cell Anemia
Single Nucleotide Polymorphism
Isoantibodies
Erythrocyte Transfusion
Biomarkers
Genetic Markers
Autoantibodies
Genes
B-Lymphocytes
Retrospective Studies
Erythrocytes
Prospective Studies
Therapeutics

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

Cite this

Tatari Calderone, Z., Tamouza, R., Le Bouder, G. P., Dewan, R., Luban, N. L. C., Lasserre, J., ... Vukmanovic, S. (2013). The association of CD81 polymorphisms with alloimmunization in sickle cell disease. Clinical and Developmental Immunology, 2013, [937846]. https://doi.org/10.1155/2013/937846

The association of CD81 polymorphisms with alloimmunization in sickle cell disease. / Tatari Calderone, Zohreh; Tamouza, Ryad; Le Bouder, Gama P.; Dewan, Ramita; Luban, Naomi L C; Lasserre, Jacqueline; Maury, Jacqueline; Lionnet, François; Krishnamoorthy, Rajagopal; Girot, Robert; Vukmanovic, Stanislav.

In: Clinical and Developmental Immunology, Vol. 2013, 937846, 2013.

Research output: Contribution to journalArticle

Tatari Calderone, Z, Tamouza, R, Le Bouder, GP, Dewan, R, Luban, NLC, Lasserre, J, Maury, J, Lionnet, F, Krishnamoorthy, R, Girot, R & Vukmanovic, S 2013, 'The association of CD81 polymorphisms with alloimmunization in sickle cell disease', Clinical and Developmental Immunology, vol. 2013, 937846. https://doi.org/10.1155/2013/937846
Tatari Calderone, Zohreh ; Tamouza, Ryad ; Le Bouder, Gama P. ; Dewan, Ramita ; Luban, Naomi L C ; Lasserre, Jacqueline ; Maury, Jacqueline ; Lionnet, François ; Krishnamoorthy, Rajagopal ; Girot, Robert ; Vukmanovic, Stanislav. / The association of CD81 polymorphisms with alloimmunization in sickle cell disease. In: Clinical and Developmental Immunology. 2013 ; Vol. 2013.
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