The association between various smoking behaviors, cotinine biomarkers and skin autofluorescence, a marker for advanced glycation end product accumulation

Robert P. Van Waateringe, Marjonneke J. Mook-Kanamori, Sandra N. Slagter, Melanie M. Van Der Klauw, Jana V. Van Vliet-Ostaptchouk, Reindert Graaff, Helen L. Lutgers, Karsten Suhre, Mohammed M. El-Din Selim, Dennis O. Mook-Kanamori, Bruce H.R. Wolffenbuttel

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Skin autofluorescence, a biomarker for advanced glycation end products (AGEs) accumulation, has been shown to predict diabetes-related cardiovascular complications and is associated with several environmental and lifestyle factors. In the present study, we examined the association between various smoking behaviors and skin autofluorescence, as well as the association between several cotinine biomarkers and skin autofluorescence, using both epidemiological and metabolomics data. Methods: In a cross-sectional study, we evaluated participants from the LifeLines Cohort Study and the Qatar Metabolomics Study on Diabetes (QMDiab). In the LifeLines Cohort Study smoking behavior and secondhand smoking were assessed in 8,905 individuals including 309 individuals (3.5%) with type 2 diabetes. In QMDiab, cotinine biomarkers were measured in saliva, plasma and urine in 364 individuals of whom 188 (51%) had type 2 diabetes. Skin autofluorescence was measured non-invasively in all participants using the AGE Reader. Results: Skin autofluorescence levels increased with a higher number of hours being exposed to secondhand smoking. Skin autofluorescence levels of former smokers approached levels of never smokers after around 15 years of smoking cessation. Urinary cotinine N-oxide, a biomarker of nicotine exposure, was found to be positively associated with skin autofluorescence in the QMDiab study (p = 0.03). Conclusions: In the present study, we have demonstrated that secondhand smoking is associated with higher skin autofluorescence levels whereas smoking cessation has a beneficial effect on skin autofluorescence. Finally, urinary cotinine N-oxide might be used as an alternative way for questionnaires to examine the effect of (environmental) tobacco smoking on skin autofluorescence.

Original languageEnglish
Article numbere0179330
JournalPLoS One
Volume12
Issue number6
DOIs
Publication statusPublished - 1 Jun 2017

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Cotinine
Advanced Glycosylation End Products
Biomarkers
skin (animal)
biomarkers
Skin
Smoking
Association reactions
Medical problems
Metabolomics
Qatar
metabolomics
Tobacco Smoke Pollution
diabetes
Smoking Cessation
cohort studies
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
oxides
Cohort Studies

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Van Waateringe, R. P., Mook-Kanamori, M. J., Slagter, S. N., Van Der Klauw, M. M., Van Vliet-Ostaptchouk, J. V., Graaff, R., ... Wolffenbuttel, B. H. R. (2017). The association between various smoking behaviors, cotinine biomarkers and skin autofluorescence, a marker for advanced glycation end product accumulation. PLoS One, 12(6), [e0179330]. https://doi.org/10.1371/journal.pone.0179330

The association between various smoking behaviors, cotinine biomarkers and skin autofluorescence, a marker for advanced glycation end product accumulation. / Van Waateringe, Robert P.; Mook-Kanamori, Marjonneke J.; Slagter, Sandra N.; Van Der Klauw, Melanie M.; Van Vliet-Ostaptchouk, Jana V.; Graaff, Reindert; Lutgers, Helen L.; Suhre, Karsten; El-Din Selim, Mohammed M.; Mook-Kanamori, Dennis O.; Wolffenbuttel, Bruce H.R.

In: PLoS One, Vol. 12, No. 6, e0179330, 01.06.2017.

Research output: Contribution to journalArticle

Van Waateringe, RP, Mook-Kanamori, MJ, Slagter, SN, Van Der Klauw, MM, Van Vliet-Ostaptchouk, JV, Graaff, R, Lutgers, HL, Suhre, K, El-Din Selim, MM, Mook-Kanamori, DO & Wolffenbuttel, BHR 2017, 'The association between various smoking behaviors, cotinine biomarkers and skin autofluorescence, a marker for advanced glycation end product accumulation', PLoS One, vol. 12, no. 6, e0179330. https://doi.org/10.1371/journal.pone.0179330
Van Waateringe RP, Mook-Kanamori MJ, Slagter SN, Van Der Klauw MM, Van Vliet-Ostaptchouk JV, Graaff R et al. The association between various smoking behaviors, cotinine biomarkers and skin autofluorescence, a marker for advanced glycation end product accumulation. PLoS One. 2017 Jun 1;12(6). e0179330. https://doi.org/10.1371/journal.pone.0179330
Van Waateringe, Robert P. ; Mook-Kanamori, Marjonneke J. ; Slagter, Sandra N. ; Van Der Klauw, Melanie M. ; Van Vliet-Ostaptchouk, Jana V. ; Graaff, Reindert ; Lutgers, Helen L. ; Suhre, Karsten ; El-Din Selim, Mohammed M. ; Mook-Kanamori, Dennis O. ; Wolffenbuttel, Bruce H.R. / The association between various smoking behaviors, cotinine biomarkers and skin autofluorescence, a marker for advanced glycation end product accumulation. In: PLoS One. 2017 ; Vol. 12, No. 6.
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AU - Van Der Klauw, Melanie M.

AU - Van Vliet-Ostaptchouk, Jana V.

AU - Graaff, Reindert

AU - Lutgers, Helen L.

AU - Suhre, Karsten

AU - El-Din Selim, Mohammed M.

AU - Mook-Kanamori, Dennis O.

AU - Wolffenbuttel, Bruce H.R.

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