The acute effects of ultraviolet radiation on the blood transcriptome are independent of plasma 25OHD3

Mariona Bustamante, Carles Hernandez-Ferrer, Yaris Sarria, Graham I. Harrison, Lara Nonell, Wenjing Kang, Marc R. Friedländer, Xavier P. Estivill, Juan R. González, Mark Nieuwenhuijsen, Antony R. Young

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Abstract

The molecular basis of many health outcomes attributed to solar ultraviolet radiation (UVR) is unknown. We tested the hypothesis that they may originate from transcriptional changes in blood cells. This was determined by assessing the effect of fluorescent solar simulated radiation (FSSR) on the transcriptional profile of peripheral blood pre- and 6 h, 24 h and 48 h post-exposure in nine healthy volunteers. Expression of 20 genes was down-regulated and one was up-regulated at 6 h after FSSR. All recovered to baseline expression at 24 h or 48 h. These genes have been associated with immune regulation, cancer and blood pressure; health effects attributed to vitamin D via solar UVR exposure. Plasma 25-hydroxyvitamin D3 [25OHD3] levels increased over time after FSSR and were maximal at 48 h. The increase was more pronounced in participants with low basal 25OHD3 levels. Mediation analyses suggested that changes in gene expression due to FSSR were independent of 25OHD3 and blood cell subpopulations.

Original languageEnglish
Pages (from-to)239-248
Number of pages10
JournalEnvironmental Research
Volume159
DOIs
Publication statusPublished - 1 Jan 2017

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Keywords

  • Blood
  • Gene expression
  • MiRNA expression
  • Solar ultraviolet radiation
  • Vitamin D

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Science(all)

Cite this

Bustamante, M., Hernandez-Ferrer, C., Sarria, Y., Harrison, G. I., Nonell, L., Kang, W., Friedländer, M. R., Estivill, X. P., González, J. R., Nieuwenhuijsen, M., & Young, A. R. (2017). The acute effects of ultraviolet radiation on the blood transcriptome are independent of plasma 25OHD3. Environmental Research, 159, 239-248. https://doi.org/10.1016/j.envres.2017.07.045