The action of the ionophores, X-537A and A-23187, on smooth muscle

V. C. Swamy, M. Ticku, Christopher Triggle, D. J. Triggle

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The cation ionophore X 537A in the concentration range of 10-6 to 3 x 10-5 M produced contractions in the rat and guinea pig vas deferens. No contractile effect was produced in either of the vasa deferentia preparations by the ionophore A 23187 in the concentration range of 10-7 to 5 x 10-5M. In contrast X 537A had no contractile effect on the guinea pig ileal longitudinal smooth muscle while A 23187 produced a dose and [Ca2+] dependent contraction. The contractile effect of X 537A in the vasa deferentia preparations is abolished by phenoxybenzamine or prior reserpine treatment and is therefore attributed to the release of norepinephrine. The effect of A 23187 in the intestinal smooth muscle is attributed to a direct Ca2+ transporting action since its contractile effect is unaffected by histamine, acetylcholine, or 5 hydroxytryptamine antagonists.

Original languageEnglish
Pages (from-to)1108-1114
Number of pages7
JournalCanadian Journal of Physiology and Pharmacology
Volume53
Issue number6
Publication statusPublished - 1975
Externally publishedYes

Fingerprint

Lasalocid
Ionophores
Calcimycin
Smooth Muscle
Guinea Pigs
Phenoxybenzamine
Serotonin Antagonists
Vas Deferens
Reserpine
Histamine
Acetylcholine
Cations
Norepinephrine

ASJC Scopus subject areas

  • Physiology
  • Pharmacology

Cite this

The action of the ionophores, X-537A and A-23187, on smooth muscle. / Swamy, V. C.; Ticku, M.; Triggle, Christopher; Triggle, D. J.

In: Canadian Journal of Physiology and Pharmacology, Vol. 53, No. 6, 1975, p. 1108-1114.

Research output: Contribution to journalArticle

@article{b2656f71d00840368899c367be524277,
title = "The action of the ionophores, X-537A and A-23187, on smooth muscle",
abstract = "The cation ionophore X 537A in the concentration range of 10-6 to 3 x 10-5 M produced contractions in the rat and guinea pig vas deferens. No contractile effect was produced in either of the vasa deferentia preparations by the ionophore A 23187 in the concentration range of 10-7 to 5 x 10-5M. In contrast X 537A had no contractile effect on the guinea pig ileal longitudinal smooth muscle while A 23187 produced a dose and [Ca2+] dependent contraction. The contractile effect of X 537A in the vasa deferentia preparations is abolished by phenoxybenzamine or prior reserpine treatment and is therefore attributed to the release of norepinephrine. The effect of A 23187 in the intestinal smooth muscle is attributed to a direct Ca2+ transporting action since its contractile effect is unaffected by histamine, acetylcholine, or 5 hydroxytryptamine antagonists.",
author = "Swamy, {V. C.} and M. Ticku and Christopher Triggle and Triggle, {D. J.}",
year = "1975",
language = "English",
volume = "53",
pages = "1108--1114",
journal = "Canadian Journal of Physiology and Pharmacology",
issn = "0008-4212",
publisher = "National Research Council of Canada",
number = "6",

}

TY - JOUR

T1 - The action of the ionophores, X-537A and A-23187, on smooth muscle

AU - Swamy, V. C.

AU - Ticku, M.

AU - Triggle, Christopher

AU - Triggle, D. J.

PY - 1975

Y1 - 1975

N2 - The cation ionophore X 537A in the concentration range of 10-6 to 3 x 10-5 M produced contractions in the rat and guinea pig vas deferens. No contractile effect was produced in either of the vasa deferentia preparations by the ionophore A 23187 in the concentration range of 10-7 to 5 x 10-5M. In contrast X 537A had no contractile effect on the guinea pig ileal longitudinal smooth muscle while A 23187 produced a dose and [Ca2+] dependent contraction. The contractile effect of X 537A in the vasa deferentia preparations is abolished by phenoxybenzamine or prior reserpine treatment and is therefore attributed to the release of norepinephrine. The effect of A 23187 in the intestinal smooth muscle is attributed to a direct Ca2+ transporting action since its contractile effect is unaffected by histamine, acetylcholine, or 5 hydroxytryptamine antagonists.

AB - The cation ionophore X 537A in the concentration range of 10-6 to 3 x 10-5 M produced contractions in the rat and guinea pig vas deferens. No contractile effect was produced in either of the vasa deferentia preparations by the ionophore A 23187 in the concentration range of 10-7 to 5 x 10-5M. In contrast X 537A had no contractile effect on the guinea pig ileal longitudinal smooth muscle while A 23187 produced a dose and [Ca2+] dependent contraction. The contractile effect of X 537A in the vasa deferentia preparations is abolished by phenoxybenzamine or prior reserpine treatment and is therefore attributed to the release of norepinephrine. The effect of A 23187 in the intestinal smooth muscle is attributed to a direct Ca2+ transporting action since its contractile effect is unaffected by histamine, acetylcholine, or 5 hydroxytryptamine antagonists.

UR - http://www.scopus.com/inward/record.url?scp=0016676924&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016676924&partnerID=8YFLogxK

M3 - Article

VL - 53

SP - 1108

EP - 1114

JO - Canadian Journal of Physiology and Pharmacology

JF - Canadian Journal of Physiology and Pharmacology

SN - 0008-4212

IS - 6

ER -