The action of the ionophores, X-537A and A-23187, on smooth muscle

V. C. Swamy, M. Ticku, C. R. Triggle, D. J. Triggle

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The cation ionophore X 537A in the concentration range of 10-6 to 3 x 10-5 M produced contractions in the rat and guinea pig vas deferens. No contractile effect was produced in either of the vasa deferentia preparations by the ionophore A 23187 in the concentration range of 10-7 to 5 x 10-5M. In contrast X 537A had no contractile effect on the guinea pig ileal longitudinal smooth muscle while A 23187 produced a dose and [Ca2+] dependent contraction. The contractile effect of X 537A in the vasa deferentia preparations is abolished by phenoxybenzamine or prior reserpine treatment and is therefore attributed to the release of norepinephrine. The effect of A 23187 in the intestinal smooth muscle is attributed to a direct Ca2+ transporting action since its contractile effect is unaffected by histamine, acetylcholine, or 5 hydroxytryptamine antagonists.

Original languageEnglish
Pages (from-to)1108-1114
Number of pages7
JournalCanadian Journal of Physiology and Pharmacology
Issue number6
Publication statusPublished - 1 Jan 1975


ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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