The 5-ht2a -1438g/a polymorphism in anorexia nervosa

A combined analysis of 316 trios from six european centres

Philip Gorwood, J. Adès, L. Bellodi, E. Cellini, D. A. Collier, D. Di Bella, M. Di Bernardo, Xavier P. Estivill, F. Fernandez-Aranda, M. Gratacos, J. Hebebrand, A. Hinney, X. Hu, A. Karwautz, A. Kipman, M. C. Mouren-Siméoni, B. Nacmias, M. Ribasés, H. Remschmidt, V. Ricca & 3 others C. M. Rotella, S. Sorbi, J. Treasure

Research output: Contribution to journalArticle

Abstract

Several case-control association studies have raised the possibility that the A allele of a -1438 G/A polymorphism in the type 2A serotonin receptor (HTR2A) gene may be a risk factor for anorexia nervosa. However the absence of linkage and the existence of negative association studies raise the possibility of false positive findings, resulting from population stratification or lack of statistical power. To address this controversy we recruited a sample of 316 patients with anorexia nervosa from six European centres, and utilised a family-based transmission disequilibrium (TDT) approach to analyse the HTR2A-1438 G/A polymorphism. Age at onset and minimal BMI were also taken into consideration in order to detect clinical heterogeneity or a quantitative trait effect. The TDT approach showed that the A allele was transmitted 133 times and not transmitted 148 times (McNemar χ2 = 0.29, df = 1, P = 0.59). Also, the haplotype-based haplotype relative risk method showed no evidence for association of the A allele, in samples from each centre (χ2 < 2.15, df = 1, P > 0.14) and in the total sample (χ2 = 0.55, df = 1; P = 0.46). Furthermore, we found no evidence for heterogeneity of the A allele frequency between samples (χ2 = 2.54, df = 4, P = 0.64), either according to minimal-BMI (F1/242 = 2.14, P = 0.45) or age at onset (F1/224 = 2.39; P = 0.12). QTL-TDT analyses also showed no direct role of the A allele on these traits. We thus found no evidence for a significant role of the 5-HT2A gene in anorexia nervosa. Previous results may have been exposed to stratification bias (which we controlled by the TDT method) and/or the risk of type 1 error (from which we were less exposed because of the sample size).

Original languageEnglish
Pages (from-to)90-94
Number of pages5
JournalMolecular Psychiatry
Volume7
Issue number1
DOIs
Publication statusPublished - 2002
Externally publishedYes

Fingerprint

Anorexia Nervosa
Alleles
Age of Onset
Haplotypes
Receptor, Serotonin, 5-HT2A
Gene Frequency
Sample Size
Genes
Case-Control Studies
Population

Keywords

  • Eating disorder
  • Qtl (quantitative trait loci)
  • Serotonin
  • Tdt (transmission disequilibrium test)

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health

Cite this

Gorwood, P., Adès, J., Bellodi, L., Cellini, E., Collier, D. A., Di Bella, D., ... Treasure, J. (2002). The 5-ht2a -1438g/a polymorphism in anorexia nervosa: A combined analysis of 316 trios from six european centres. Molecular Psychiatry, 7(1), 90-94. https://doi.org/10.1038/sj/mp/4001938

The 5-ht2a -1438g/a polymorphism in anorexia nervosa : A combined analysis of 316 trios from six european centres. / Gorwood, Philip; Adès, J.; Bellodi, L.; Cellini, E.; Collier, D. A.; Di Bella, D.; Di Bernardo, M.; Estivill, Xavier P.; Fernandez-Aranda, F.; Gratacos, M.; Hebebrand, J.; Hinney, A.; Hu, X.; Karwautz, A.; Kipman, A.; Mouren-Siméoni, M. C.; Nacmias, B.; Ribasés, M.; Remschmidt, H.; Ricca, V.; Rotella, C. M.; Sorbi, S.; Treasure, J.

In: Molecular Psychiatry, Vol. 7, No. 1, 2002, p. 90-94.

Research output: Contribution to journalArticle

Gorwood, P, Adès, J, Bellodi, L, Cellini, E, Collier, DA, Di Bella, D, Di Bernardo, M, Estivill, XP, Fernandez-Aranda, F, Gratacos, M, Hebebrand, J, Hinney, A, Hu, X, Karwautz, A, Kipman, A, Mouren-Siméoni, MC, Nacmias, B, Ribasés, M, Remschmidt, H, Ricca, V, Rotella, CM, Sorbi, S & Treasure, J 2002, 'The 5-ht2a -1438g/a polymorphism in anorexia nervosa: A combined analysis of 316 trios from six european centres', Molecular Psychiatry, vol. 7, no. 1, pp. 90-94. https://doi.org/10.1038/sj/mp/4001938
Gorwood, Philip ; Adès, J. ; Bellodi, L. ; Cellini, E. ; Collier, D. A. ; Di Bella, D. ; Di Bernardo, M. ; Estivill, Xavier P. ; Fernandez-Aranda, F. ; Gratacos, M. ; Hebebrand, J. ; Hinney, A. ; Hu, X. ; Karwautz, A. ; Kipman, A. ; Mouren-Siméoni, M. C. ; Nacmias, B. ; Ribasés, M. ; Remschmidt, H. ; Ricca, V. ; Rotella, C. M. ; Sorbi, S. ; Treasure, J. / The 5-ht2a -1438g/a polymorphism in anorexia nervosa : A combined analysis of 316 trios from six european centres. In: Molecular Psychiatry. 2002 ; Vol. 7, No. 1. pp. 90-94.
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