The 350-fold compacted Fugu parkin gene is structurally and functionally similar to human Parkin

Wei Ping Yu, Jeanne M M Tan, Katherine C M Chew, Tania Oh, Prasanna Kolatkar, Byrappa Venkatesh, Ted M. Dawson, Kah Leong Lim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Mutations in the human parkin gene (huParkin) are the predominant genetic cause of familial parkinsonism. The huParkin locus, spanning about 1.4 Mb, is one of the largest in the human genome. Despite its huge size, huParkin codes for a rather short transcript of about 4.5 kb. To gain an insight into the structure, function and evolutionary history of huParkin, we have characterized the pufferfish [Fugu rubripes (Fugu)] ortholog of huParkin. A remarkable feature of the Fugu parkin gene (fuparkin) is its unusually compact size. It spans only about 4 kb and is thus 350-fold smaller than its human ortholog. The Fugu and human parkin genes are otherwise highly similar in their genomic organization and expression pattern. Furthermore, like human Parkin, Fugu parkin also functions as an ubiquitin ligase. These shared features between fuparkin and huParkin suggest that the physiological function and regulation of the parkin gene are conserved during the evolution of vertebrates. Conceivably, the compact locus of fuparkin could serve as a useful model to understand the transcriptional regulation of huParkin.

Original languageEnglish
Pages (from-to)97-104
Number of pages8
JournalGene
Volume346
DOIs
Publication statusPublished - 14 Feb 2005
Externally publishedYes

Fingerprint

Takifugu
Genes
Tetraodontiformes
Parkinsonian Disorders
Human Genome
Ligases
Ubiquitin

Keywords

  • Dystrophin
  • Parkinson's disease
  • Transcriptional regulation
  • Ubiquitin ligase

ASJC Scopus subject areas

  • Genetics

Cite this

Yu, W. P., Tan, J. M. M., Chew, K. C. M., Oh, T., Kolatkar, P., Venkatesh, B., ... Lim, K. L. (2005). The 350-fold compacted Fugu parkin gene is structurally and functionally similar to human Parkin. Gene, 346, 97-104. https://doi.org/10.1016/j.gene.2004.09.022

The 350-fold compacted Fugu parkin gene is structurally and functionally similar to human Parkin. / Yu, Wei Ping; Tan, Jeanne M M; Chew, Katherine C M; Oh, Tania; Kolatkar, Prasanna; Venkatesh, Byrappa; Dawson, Ted M.; Lim, Kah Leong.

In: Gene, Vol. 346, 14.02.2005, p. 97-104.

Research output: Contribution to journalArticle

Yu, WP, Tan, JMM, Chew, KCM, Oh, T, Kolatkar, P, Venkatesh, B, Dawson, TM & Lim, KL 2005, 'The 350-fold compacted Fugu parkin gene is structurally and functionally similar to human Parkin', Gene, vol. 346, pp. 97-104. https://doi.org/10.1016/j.gene.2004.09.022
Yu, Wei Ping ; Tan, Jeanne M M ; Chew, Katherine C M ; Oh, Tania ; Kolatkar, Prasanna ; Venkatesh, Byrappa ; Dawson, Ted M. ; Lim, Kah Leong. / The 350-fold compacted Fugu parkin gene is structurally and functionally similar to human Parkin. In: Gene. 2005 ; Vol. 346. pp. 97-104.
@article{6d91dc2ed030491d835a37fa1bcd709b,
title = "The 350-fold compacted Fugu parkin gene is structurally and functionally similar to human Parkin",
abstract = "Mutations in the human parkin gene (huParkin) are the predominant genetic cause of familial parkinsonism. The huParkin locus, spanning about 1.4 Mb, is one of the largest in the human genome. Despite its huge size, huParkin codes for a rather short transcript of about 4.5 kb. To gain an insight into the structure, function and evolutionary history of huParkin, we have characterized the pufferfish [Fugu rubripes (Fugu)] ortholog of huParkin. A remarkable feature of the Fugu parkin gene (fuparkin) is its unusually compact size. It spans only about 4 kb and is thus 350-fold smaller than its human ortholog. The Fugu and human parkin genes are otherwise highly similar in their genomic organization and expression pattern. Furthermore, like human Parkin, Fugu parkin also functions as an ubiquitin ligase. These shared features between fuparkin and huParkin suggest that the physiological function and regulation of the parkin gene are conserved during the evolution of vertebrates. Conceivably, the compact locus of fuparkin could serve as a useful model to understand the transcriptional regulation of huParkin.",
keywords = "Dystrophin, Parkinson's disease, Transcriptional regulation, Ubiquitin ligase",
author = "Yu, {Wei Ping} and Tan, {Jeanne M M} and Chew, {Katherine C M} and Tania Oh and Prasanna Kolatkar and Byrappa Venkatesh and Dawson, {Ted M.} and Lim, {Kah Leong}",
year = "2005",
month = "2",
day = "14",
doi = "10.1016/j.gene.2004.09.022",
language = "English",
volume = "346",
pages = "97--104",
journal = "Gene",
issn = "0378-1119",
publisher = "Elsevier",

}

TY - JOUR

T1 - The 350-fold compacted Fugu parkin gene is structurally and functionally similar to human Parkin

AU - Yu, Wei Ping

AU - Tan, Jeanne M M

AU - Chew, Katherine C M

AU - Oh, Tania

AU - Kolatkar, Prasanna

AU - Venkatesh, Byrappa

AU - Dawson, Ted M.

AU - Lim, Kah Leong

PY - 2005/2/14

Y1 - 2005/2/14

N2 - Mutations in the human parkin gene (huParkin) are the predominant genetic cause of familial parkinsonism. The huParkin locus, spanning about 1.4 Mb, is one of the largest in the human genome. Despite its huge size, huParkin codes for a rather short transcript of about 4.5 kb. To gain an insight into the structure, function and evolutionary history of huParkin, we have characterized the pufferfish [Fugu rubripes (Fugu)] ortholog of huParkin. A remarkable feature of the Fugu parkin gene (fuparkin) is its unusually compact size. It spans only about 4 kb and is thus 350-fold smaller than its human ortholog. The Fugu and human parkin genes are otherwise highly similar in their genomic organization and expression pattern. Furthermore, like human Parkin, Fugu parkin also functions as an ubiquitin ligase. These shared features between fuparkin and huParkin suggest that the physiological function and regulation of the parkin gene are conserved during the evolution of vertebrates. Conceivably, the compact locus of fuparkin could serve as a useful model to understand the transcriptional regulation of huParkin.

AB - Mutations in the human parkin gene (huParkin) are the predominant genetic cause of familial parkinsonism. The huParkin locus, spanning about 1.4 Mb, is one of the largest in the human genome. Despite its huge size, huParkin codes for a rather short transcript of about 4.5 kb. To gain an insight into the structure, function and evolutionary history of huParkin, we have characterized the pufferfish [Fugu rubripes (Fugu)] ortholog of huParkin. A remarkable feature of the Fugu parkin gene (fuparkin) is its unusually compact size. It spans only about 4 kb and is thus 350-fold smaller than its human ortholog. The Fugu and human parkin genes are otherwise highly similar in their genomic organization and expression pattern. Furthermore, like human Parkin, Fugu parkin also functions as an ubiquitin ligase. These shared features between fuparkin and huParkin suggest that the physiological function and regulation of the parkin gene are conserved during the evolution of vertebrates. Conceivably, the compact locus of fuparkin could serve as a useful model to understand the transcriptional regulation of huParkin.

KW - Dystrophin

KW - Parkinson's disease

KW - Transcriptional regulation

KW - Ubiquitin ligase

UR - http://www.scopus.com/inward/record.url?scp=14744297780&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=14744297780&partnerID=8YFLogxK

U2 - 10.1016/j.gene.2004.09.022

DO - 10.1016/j.gene.2004.09.022

M3 - Article

VL - 346

SP - 97

EP - 104

JO - Gene

JF - Gene

SN - 0378-1119

ER -