Telomeres and the natural lifespan limit in humans

Troels Steenstrup, Jeremy D. Kark, Simon Verhulst, Mikael Thinggaard, Jacob V.B. Hjelmborg, Christine Dalgård, Kirsten Ohm Kyvik, Lene Christiansen, Massimo Mangino, Timothy D. Spector, Inge Petersen, Masayuki Kimura, Athanase Benetos, Carlos Labat, Ronit Sinnreich, Shih Jen Hwang, Daniel Levy, Steven Hunt, Annette L. Fitzpatrick, Wei Chen & 9 others Gerald S. Berenson, Michelangela Barbieri, Giuseppe Paolisso, Shahinaz M. Gadalla, Sharon A. Savage, Kaare Christensen, Anatoliy I. Yashin, Konstantin G. Arbeev, Abraham Aviv

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

An ongoing debate in demography has focused on whether the human lifespan has a maximal natural limit. Taking a mechanistic perspective, and knowing that short telomeres are associated with diminished longevity, we examined whether telomere length dynamics during adult life could set a maximal natural lifespan limit. We define leukocyte telomere length of 5 kb as the 'telomeric brink', which denotes a high risk of imminent death. We show that a subset of adults may reach the telomeric brink within the current life expectancy and more so for a 100-year life expectancy. Thus secular trends in life expectancy should confront a biological limit due to crossing the telomeric brink.

Original languageEnglish
Pages (from-to)1130-1142
Number of pages13
JournalAging
Volume9
Issue number4
DOIs
Publication statusPublished - 1 Jan 2017
Externally publishedYes

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Telomere
Life Expectancy
Leukocytes
Demography

Keywords

  • Leukocytes
  • Life-expectancy
  • Longevity
  • Maximal lifespan
  • Sex

ASJC Scopus subject areas

  • Ageing
  • Cell Biology

Cite this

Steenstrup, T., Kark, J. D., Verhulst, S., Thinggaard, M., Hjelmborg, J. V. B., Dalgård, C., ... Aviv, A. (2017). Telomeres and the natural lifespan limit in humans. Aging, 9(4), 1130-1142. https://doi.org/10.18632/aging.101216

Telomeres and the natural lifespan limit in humans. / Steenstrup, Troels; Kark, Jeremy D.; Verhulst, Simon; Thinggaard, Mikael; Hjelmborg, Jacob V.B.; Dalgård, Christine; Kyvik, Kirsten Ohm; Christiansen, Lene; Mangino, Massimo; Spector, Timothy D.; Petersen, Inge; Kimura, Masayuki; Benetos, Athanase; Labat, Carlos; Sinnreich, Ronit; Hwang, Shih Jen; Levy, Daniel; Hunt, Steven; Fitzpatrick, Annette L.; Chen, Wei; Berenson, Gerald S.; Barbieri, Michelangela; Paolisso, Giuseppe; Gadalla, Shahinaz M.; Savage, Sharon A.; Christensen, Kaare; Yashin, Anatoliy I.; Arbeev, Konstantin G.; Aviv, Abraham.

In: Aging, Vol. 9, No. 4, 01.01.2017, p. 1130-1142.

Research output: Contribution to journalArticle

Steenstrup, T, Kark, JD, Verhulst, S, Thinggaard, M, Hjelmborg, JVB, Dalgård, C, Kyvik, KO, Christiansen, L, Mangino, M, Spector, TD, Petersen, I, Kimura, M, Benetos, A, Labat, C, Sinnreich, R, Hwang, SJ, Levy, D, Hunt, S, Fitzpatrick, AL, Chen, W, Berenson, GS, Barbieri, M, Paolisso, G, Gadalla, SM, Savage, SA, Christensen, K, Yashin, AI, Arbeev, KG & Aviv, A 2017, 'Telomeres and the natural lifespan limit in humans', Aging, vol. 9, no. 4, pp. 1130-1142. https://doi.org/10.18632/aging.101216
Steenstrup T, Kark JD, Verhulst S, Thinggaard M, Hjelmborg JVB, Dalgård C et al. Telomeres and the natural lifespan limit in humans. Aging. 2017 Jan 1;9(4):1130-1142. https://doi.org/10.18632/aging.101216
Steenstrup, Troels ; Kark, Jeremy D. ; Verhulst, Simon ; Thinggaard, Mikael ; Hjelmborg, Jacob V.B. ; Dalgård, Christine ; Kyvik, Kirsten Ohm ; Christiansen, Lene ; Mangino, Massimo ; Spector, Timothy D. ; Petersen, Inge ; Kimura, Masayuki ; Benetos, Athanase ; Labat, Carlos ; Sinnreich, Ronit ; Hwang, Shih Jen ; Levy, Daniel ; Hunt, Steven ; Fitzpatrick, Annette L. ; Chen, Wei ; Berenson, Gerald S. ; Barbieri, Michelangela ; Paolisso, Giuseppe ; Gadalla, Shahinaz M. ; Savage, Sharon A. ; Christensen, Kaare ; Yashin, Anatoliy I. ; Arbeev, Konstantin G. ; Aviv, Abraham. / Telomeres and the natural lifespan limit in humans. In: Aging. 2017 ; Vol. 9, No. 4. pp. 1130-1142.
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