Telomere length, telomeric proteins and genomic instability during the multistep carcinogenic process

Christophe M. Raynaud, Laure Sabatier, Ophelie Philipot, Ken André Olaussen, Jean Charles Soria

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Telomeres form specialized structures at the ends of eukaryotic chromosomes, preventing them from being wrongly recognized as DNA damage. The human telomere DNA sequence is a tandem repetition of the sequence TTAGGG. In normal cells, the DNA replication machinery is unable to completely duplicate the telomeric DNA; thus, telomeres are shortened after every cell division. Having reached a critical length, telomeres may be recognized as double strand break DNA lesions, and cells eventually enter senescence. Carcinogenesis is a multistep process involving multiple mutations and chromosomal aberrations. One of the most prevalent aberrations in pre-cancerous lesions is telomere shortening and telomerase activation. We discuss the role and homeostasis of telomeres in normal cells and their implication in the early steps of carcinogenesis. We also discuss various techniques used, and their limitations, in the study of telomeres and genome instability and their role in carcinogenesis and related genomic modifications.

Original languageEnglish
Pages (from-to)99-117
Number of pages19
JournalCritical Reviews in Oncology/Hematology
Volume66
Issue number2
DOIs
Publication statusPublished - 1 May 2008
Externally publishedYes

Fingerprint

Genomic Instability
Telomere
Telomere Shortening
Carcinogenesis
Proteins
Telomere Homeostasis
Double-Stranded DNA Breaks
Telomerase
DNA Replication
Chromosome Aberrations
Cell Division
DNA Damage
Chromosomes
Mutation
DNA

Keywords

  • Carcinogenesis
  • DNA damage repair
  • Telomerase
  • Telomeres

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Telomere length, telomeric proteins and genomic instability during the multistep carcinogenic process. / Raynaud, Christophe M.; Sabatier, Laure; Philipot, Ophelie; Olaussen, Ken André; Soria, Jean Charles.

In: Critical Reviews in Oncology/Hematology, Vol. 66, No. 2, 01.05.2008, p. 99-117.

Research output: Contribution to journalArticle

Raynaud, Christophe M. ; Sabatier, Laure ; Philipot, Ophelie ; Olaussen, Ken André ; Soria, Jean Charles. / Telomere length, telomeric proteins and genomic instability during the multistep carcinogenic process. In: Critical Reviews in Oncology/Hematology. 2008 ; Vol. 66, No. 2. pp. 99-117.
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