Abstract
Introduction: α-Synuclein, a neuronal protein, plays a central role in the pathophysiology of Parkinsons disease (PD), the second most prevalent neurodegenerative disorder. Cases of PD have increased tremendously over the past decade necessitating the identification of new therapeutic targets to reduce patient morbidity and to improve PD patients quality of life.Areas covered: The purpose of this article is to provide an update on the role of α-synuclein in fibrils formation and review its role as an effective immunotherapeutic target for PD. The rapidly expanding evidence for the contribution of α-synuclein to the pathogenesis of PD led to the development of antibodies against the C terminus of α-synuclein and other molecules involved in the inflammatory signaling pathways that were found to contribute significantly to initiation and progression of the disease.Expert opinion: The readers will obtain new insights on the mechanisms by which α-synuclein can trigger the development of PD and other related degenerative disorders along with the potential role of active and passive antibodies targeted against specific form of α-synuclein aggregates to clear neurotoxicity, stop the propagation of the prion-like behavior of these oligomers and reverse neuronal degeneration associated with PD.
| Original language | English |
|---|---|
| Pages (from-to) | 1351-1360 |
| Number of pages | 10 |
| Journal | Expert Opinion on Therapeutic Targets |
| Volume | 19 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 3 Oct 2015 |
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Keywords
- immunotherapy
- inflammation
- Lewy bodies
- neurodegenerative disorder
- Parkinson's disease
- synucleinopathies
- α-synuclein
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology
- Drug Discovery
- Clinical Biochemistry
Cite this
Targeting α-synuclein as a therapeutic strategy for Parkinsons disease. / Lawand, Nada B.; Saadé, Nayef E.; Ali El-Agnaf, Omar; Safieh-Garabedian, Bared.
In: Expert Opinion on Therapeutic Targets, Vol. 19, No. 10, 03.10.2015, p. 1351-1360.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Targeting α-synuclein as a therapeutic strategy for Parkinsons disease
AU - Lawand, Nada B.
AU - Saadé, Nayef E.
AU - Ali El-Agnaf, Omar
AU - Safieh-Garabedian, Bared
PY - 2015/10/3
Y1 - 2015/10/3
N2 - Introduction: α-Synuclein, a neuronal protein, plays a central role in the pathophysiology of Parkinsons disease (PD), the second most prevalent neurodegenerative disorder. Cases of PD have increased tremendously over the past decade necessitating the identification of new therapeutic targets to reduce patient morbidity and to improve PD patients quality of life.Areas covered: The purpose of this article is to provide an update on the role of α-synuclein in fibrils formation and review its role as an effective immunotherapeutic target for PD. The rapidly expanding evidence for the contribution of α-synuclein to the pathogenesis of PD led to the development of antibodies against the C terminus of α-synuclein and other molecules involved in the inflammatory signaling pathways that were found to contribute significantly to initiation and progression of the disease.Expert opinion: The readers will obtain new insights on the mechanisms by which α-synuclein can trigger the development of PD and other related degenerative disorders along with the potential role of active and passive antibodies targeted against specific form of α-synuclein aggregates to clear neurotoxicity, stop the propagation of the prion-like behavior of these oligomers and reverse neuronal degeneration associated with PD.
AB - Introduction: α-Synuclein, a neuronal protein, plays a central role in the pathophysiology of Parkinsons disease (PD), the second most prevalent neurodegenerative disorder. Cases of PD have increased tremendously over the past decade necessitating the identification of new therapeutic targets to reduce patient morbidity and to improve PD patients quality of life.Areas covered: The purpose of this article is to provide an update on the role of α-synuclein in fibrils formation and review its role as an effective immunotherapeutic target for PD. The rapidly expanding evidence for the contribution of α-synuclein to the pathogenesis of PD led to the development of antibodies against the C terminus of α-synuclein and other molecules involved in the inflammatory signaling pathways that were found to contribute significantly to initiation and progression of the disease.Expert opinion: The readers will obtain new insights on the mechanisms by which α-synuclein can trigger the development of PD and other related degenerative disorders along with the potential role of active and passive antibodies targeted against specific form of α-synuclein aggregates to clear neurotoxicity, stop the propagation of the prion-like behavior of these oligomers and reverse neuronal degeneration associated with PD.
KW - immunotherapy
KW - inflammation
KW - Lewy bodies
KW - neurodegenerative disorder
KW - Parkinson's disease
KW - synucleinopathies
KW - α-synuclein
UR - http://www.scopus.com/inward/record.url?scp=84941798927&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84941798927&partnerID=8YFLogxK
U2 - 10.1517/14728222.2015.1062877
DO - 10.1517/14728222.2015.1062877
M3 - Review article
VL - 19
SP - 1351
EP - 1360
JO - Expert Opinion on Therapeutic Targets
JF - Expert Opinion on Therapeutic Targets
SN - 1472-8222
IS - 10
ER -