Tardive Dyskinesia and Steady-State Serum Levels of Thiothixene

Jerome A. Yesavage, Elizabeth Decker Tanke, Javaid Sheikh

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The purpose of this investigation was to determine the relationship between serum levels of the neuroleptic agent thiothixene and tardive dyskinesia in schizophrenics of a wide age range. Forty-one male schizophrenic subjects, 21 with tardive dyskinesia and 20 without, were given a fixed dosage of thiothixene hydrochloride (10 mg orally four times daily) after a drug-free period of one week. Higher steady-state serum levels of thiothixene (obtained after five days of a fixed-dosage schedule) were associated with greater degrees of tardive dyskinesia. This relationship was independent of the relationship between tardive dyskinesia and age.

Original languageEnglish
Pages (from-to)913-915
Number of pages3
JournalArchives of General Psychiatry
Volume44
Issue number10
DOIs
Publication statusPublished - 1987
Externally publishedYes

Fingerprint

Thiothixene
Serum
Antipsychotic Agents
Appointments and Schedules
Tardive Dyskinesia
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Cite this

Tardive Dyskinesia and Steady-State Serum Levels of Thiothixene. / Yesavage, Jerome A.; Tanke, Elizabeth Decker; Sheikh, Javaid.

In: Archives of General Psychiatry, Vol. 44, No. 10, 1987, p. 913-915.

Research output: Contribution to journalArticle

Yesavage, Jerome A. ; Tanke, Elizabeth Decker ; Sheikh, Javaid. / Tardive Dyskinesia and Steady-State Serum Levels of Thiothixene. In: Archives of General Psychiatry. 1987 ; Vol. 44, No. 10. pp. 913-915.
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