Tardive Dyskinesia and Steady-State Serum Levels of Thiothixene

Jerome A. Yesavage, Elizabeth Decker Tanke, Javaid I. Sheikh

Research output: Contribution to journalArticle

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The purpose of this investigation was to determine the relationship between serum levels of the neuroleptic agent thiothixene and tardive dyskinesia in schizophrenics of a wide age range. Forty-one male schizophrenic subjects, 21 with tardive dyskinesia and 20 without, were given a fixed dosage of thiothixene hydrochloride (10 mg orally four times daily) after a drug-free period of one week. Higher steady-state serum levels of thiothixene (obtained after five days of a fixed-dosage schedule) were associated with greater degrees of tardive dyskinesia. This relationship was independent of the relationship between tardive dyskinesia and age.

Original languageEnglish
Pages (from-to)913-915
Number of pages3
JournalArchives of General Psychiatry
Issue number10
Publication statusPublished - Oct 1987


ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

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