T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility

Michella Ghassibe-Sabbagh, Marc Haber, Angelique K. Salloum, Yasser Al-Sarraj, Yasmine Akle, Kamal Hirbli, Jihane Romanos, Francis Mouzaya, Dominique Gauguier, Daniel E. Platt, Hatem El-Shanti, Pierre A. Zalloua

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Abstract

Genome-wide association studies (GWAS) of multiple populations with distinctive genetic and lifestyle backgrounds are crucial to the understanding of Type 2 Diabetes Mellitus (T2DM) pathophysiology. We report a GWAS on the genetic basis of T2DM in a 3,286 Lebanese participants. More than 5,000,000 SNPs were directly genotyped or imputed using the 1000 Genomes Project reference panels. We identify genome-wide significant variants in two loci CDKAL1 and TCF7L2, independent of sex, age and BMI, with leading variants rs7766070 (OR = 1.39, P = 4.77 × 10-9) and rs34872471 (OR = 1.35, P = 1.01 × 10-8) respectively. The current study is the first GWAS to find genomic regions implicated in T2DM in the Lebanese population. The results support a central role of CDKAL1 and TCF7L2 in T2DM susceptibility in Southwest Asian populations and provide a plausible component for understanding molecular mechanisms involved in the disease.

Original languageEnglish
Article number7351
JournalScientific reports
Volume4
DOIs
Publication statusPublished - 2014

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Ghassibe-Sabbagh, M., Haber, M., Salloum, A. K., Al-Sarraj, Y., Akle, Y., Hirbli, K., Romanos, J., Mouzaya, F., Gauguier, D., Platt, D. E., El-Shanti, H., & Zalloua, P. A. (2014). T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility. Scientific reports, 4, [7351]. https://doi.org/10.1038/srep07351