T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility

Michella Ghassibe-Sabbagh, Marc Haber, Angelique K. Salloum, Yaser Al-Sarraj, Yasmine Akle, Kamal Hirbli, Jihane Romanos, Francis Mouzaya, Dominique Gauguier, Daniel E. Platt, Hatem El-Shanti, Pierre A. Zalloua

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Genome-wide association studies (GWAS) of multiple populations with distinctive genetic and lifestyle backgrounds are crucial to the understanding of Type 2 Diabetes Mellitus (T2DM) pathophysiology. We report a GWAS on the genetic basis of T2DM in a 3,286 Lebanese participants. More than 5,000,000 SNPs were directly genotyped or imputed using the 1000 Genomes Project reference panels. We identify genome-wide significant variants in two loci CDKAL1 and TCF7L2, independent of sex, age and BMI, with leading variants rs7766070 (OR = 1.39, P = 4.77 × 10-9) and rs34872471 (OR = 1.35, P = 1.01 × 10-8) respectively. The current study is the first GWAS to find genomic regions implicated in T2DM in the Lebanese population. The results support a central role of CDKAL1 and TCF7L2 in T2DM susceptibility in Southwest Asian populations and provide a plausible component for understanding molecular mechanisms involved in the disease.

Original languageEnglish
Article number7351
JournalScientific Reports
Volume4
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Genome-Wide Association Study
Disease Susceptibility
Type 2 Diabetes Mellitus
Population
Genome
Single Nucleotide Polymorphism
Life Style

ASJC Scopus subject areas

  • General

Cite this

Ghassibe-Sabbagh, M., Haber, M., Salloum, A. K., Al-Sarraj, Y., Akle, Y., Hirbli, K., ... Zalloua, P. A. (2014). T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility. Scientific Reports, 4, [7351]. https://doi.org/10.1038/srep07351

T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility. / Ghassibe-Sabbagh, Michella; Haber, Marc; Salloum, Angelique K.; Al-Sarraj, Yaser; Akle, Yasmine; Hirbli, Kamal; Romanos, Jihane; Mouzaya, Francis; Gauguier, Dominique; Platt, Daniel E.; El-Shanti, Hatem; Zalloua, Pierre A.

In: Scientific Reports, Vol. 4, 7351, 2014.

Research output: Contribution to journalArticle

Ghassibe-Sabbagh, M, Haber, M, Salloum, AK, Al-Sarraj, Y, Akle, Y, Hirbli, K, Romanos, J, Mouzaya, F, Gauguier, D, Platt, DE, El-Shanti, H & Zalloua, PA 2014, 'T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility', Scientific Reports, vol. 4, 7351. https://doi.org/10.1038/srep07351
Ghassibe-Sabbagh, Michella ; Haber, Marc ; Salloum, Angelique K. ; Al-Sarraj, Yaser ; Akle, Yasmine ; Hirbli, Kamal ; Romanos, Jihane ; Mouzaya, Francis ; Gauguier, Dominique ; Platt, Daniel E. ; El-Shanti, Hatem ; Zalloua, Pierre A. / T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility. In: Scientific Reports. 2014 ; Vol. 4.
@article{52f4ceaa11624d328fdc07f8a3aebaec,
title = "T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility",
abstract = "Genome-wide association studies (GWAS) of multiple populations with distinctive genetic and lifestyle backgrounds are crucial to the understanding of Type 2 Diabetes Mellitus (T2DM) pathophysiology. We report a GWAS on the genetic basis of T2DM in a 3,286 Lebanese participants. More than 5,000,000 SNPs were directly genotyped or imputed using the 1000 Genomes Project reference panels. We identify genome-wide significant variants in two loci CDKAL1 and TCF7L2, independent of sex, age and BMI, with leading variants rs7766070 (OR = 1.39, P = 4.77 × 10-9) and rs34872471 (OR = 1.35, P = 1.01 × 10-8) respectively. The current study is the first GWAS to find genomic regions implicated in T2DM in the Lebanese population. The results support a central role of CDKAL1 and TCF7L2 in T2DM susceptibility in Southwest Asian populations and provide a plausible component for understanding molecular mechanisms involved in the disease.",
author = "Michella Ghassibe-Sabbagh and Marc Haber and Salloum, {Angelique K.} and Yaser Al-Sarraj and Yasmine Akle and Kamal Hirbli and Jihane Romanos and Francis Mouzaya and Dominique Gauguier and Platt, {Daniel E.} and Hatem El-Shanti and Zalloua, {Pierre A.}",
year = "2014",
doi = "10.1038/srep07351",
language = "English",
volume = "4",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility

AU - Ghassibe-Sabbagh, Michella

AU - Haber, Marc

AU - Salloum, Angelique K.

AU - Al-Sarraj, Yaser

AU - Akle, Yasmine

AU - Hirbli, Kamal

AU - Romanos, Jihane

AU - Mouzaya, Francis

AU - Gauguier, Dominique

AU - Platt, Daniel E.

AU - El-Shanti, Hatem

AU - Zalloua, Pierre A.

PY - 2014

Y1 - 2014

N2 - Genome-wide association studies (GWAS) of multiple populations with distinctive genetic and lifestyle backgrounds are crucial to the understanding of Type 2 Diabetes Mellitus (T2DM) pathophysiology. We report a GWAS on the genetic basis of T2DM in a 3,286 Lebanese participants. More than 5,000,000 SNPs were directly genotyped or imputed using the 1000 Genomes Project reference panels. We identify genome-wide significant variants in two loci CDKAL1 and TCF7L2, independent of sex, age and BMI, with leading variants rs7766070 (OR = 1.39, P = 4.77 × 10-9) and rs34872471 (OR = 1.35, P = 1.01 × 10-8) respectively. The current study is the first GWAS to find genomic regions implicated in T2DM in the Lebanese population. The results support a central role of CDKAL1 and TCF7L2 in T2DM susceptibility in Southwest Asian populations and provide a plausible component for understanding molecular mechanisms involved in the disease.

AB - Genome-wide association studies (GWAS) of multiple populations with distinctive genetic and lifestyle backgrounds are crucial to the understanding of Type 2 Diabetes Mellitus (T2DM) pathophysiology. We report a GWAS on the genetic basis of T2DM in a 3,286 Lebanese participants. More than 5,000,000 SNPs were directly genotyped or imputed using the 1000 Genomes Project reference panels. We identify genome-wide significant variants in two loci CDKAL1 and TCF7L2, independent of sex, age and BMI, with leading variants rs7766070 (OR = 1.39, P = 4.77 × 10-9) and rs34872471 (OR = 1.35, P = 1.01 × 10-8) respectively. The current study is the first GWAS to find genomic regions implicated in T2DM in the Lebanese population. The results support a central role of CDKAL1 and TCF7L2 in T2DM susceptibility in Southwest Asian populations and provide a plausible component for understanding molecular mechanisms involved in the disease.

UR - http://www.scopus.com/inward/record.url?scp=84923355952&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923355952&partnerID=8YFLogxK

U2 - 10.1038/srep07351

DO - 10.1038/srep07351

M3 - Article

C2 - 25483131

AN - SCOPUS:84923355952

VL - 4

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 7351

ER -