Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines

Gerlinde Obermoser, Scott Presnell, Kelly Domico, Hui Xu, Yuanyuan Wang, Esperanza Anguiano, Lu Ann Thompson-Snipes, Rajaram Ranganathan, Brad Zeitner, Anna Bjork, David Anderson, Cate Speake, Emily Ruchaud, Jason Skinner, Laia Alsina, Mamta Sharma, Helene Dutartre, Alma Cepika, Elisabeth Israelsson, Phuong Nguyen & 11 others Quynh Anh Nguyen, A. Carson Harrod, Sandra M. Zurawski, Virginia Pascual, Hideki Ueno, Gerald T. Nepom, Charlie Quinn, Derek Blankenship, Karolina Palucka, Jacques Banchereau, Damien J. Chaussabel

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

Systems immunology approaches were employed to investigate innate and adaptive immune responses to influenza and pneumococcal vaccines. These two non-live vaccines show different magnitudes of transcriptional responses at different time points after vaccination. Software solutions were developed to explore correlates of vaccine efficacy measured as antibody titers at day 28. These enabled a further dissection of transcriptional responses. Thus, the innate response, measured within hours in the peripheral blood, was dominated by an interferon transcriptional signature after influenza vaccination and by an inflammation signature after pneumococcal vaccination. Day 7 plasmablast responses induced by both vaccines was more pronounced after pneumococcal vaccination. Together, these results suggest that comparing global immune responses elicited by different vaccines will be critical to our understanding of the immune mechanisms underpinning successful vaccination.

Original languageEnglish
Pages (from-to)831-844
Number of pages14
JournalImmunity
Volume38
Issue number4
DOIs
Publication statusPublished - 18 Apr 2013
Externally publishedYes

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Pneumococcal Vaccines
Influenza Vaccines
Vaccination
Vaccines
Adaptive Immunity
Allergy and Immunology
Innate Immunity
Interferons
Human Influenza
Dissection
Software
Inflammation
Antibodies

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines. / Obermoser, Gerlinde; Presnell, Scott; Domico, Kelly; Xu, Hui; Wang, Yuanyuan; Anguiano, Esperanza; Thompson-Snipes, Lu Ann; Ranganathan, Rajaram; Zeitner, Brad; Bjork, Anna; Anderson, David; Speake, Cate; Ruchaud, Emily; Skinner, Jason; Alsina, Laia; Sharma, Mamta; Dutartre, Helene; Cepika, Alma; Israelsson, Elisabeth; Nguyen, Phuong; Nguyen, Quynh Anh; Harrod, A. Carson; Zurawski, Sandra M.; Pascual, Virginia; Ueno, Hideki; Nepom, Gerald T.; Quinn, Charlie; Blankenship, Derek; Palucka, Karolina; Banchereau, Jacques; Chaussabel, Damien J.

In: Immunity, Vol. 38, No. 4, 18.04.2013, p. 831-844.

Research output: Contribution to journalArticle

Obermoser, G, Presnell, S, Domico, K, Xu, H, Wang, Y, Anguiano, E, Thompson-Snipes, LA, Ranganathan, R, Zeitner, B, Bjork, A, Anderson, D, Speake, C, Ruchaud, E, Skinner, J, Alsina, L, Sharma, M, Dutartre, H, Cepika, A, Israelsson, E, Nguyen, P, Nguyen, QA, Harrod, AC, Zurawski, SM, Pascual, V, Ueno, H, Nepom, GT, Quinn, C, Blankenship, D, Palucka, K, Banchereau, J & Chaussabel, DJ 2013, 'Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines', Immunity, vol. 38, no. 4, pp. 831-844. https://doi.org/10.1016/j.immuni.2012.12.008
Obermoser, Gerlinde ; Presnell, Scott ; Domico, Kelly ; Xu, Hui ; Wang, Yuanyuan ; Anguiano, Esperanza ; Thompson-Snipes, Lu Ann ; Ranganathan, Rajaram ; Zeitner, Brad ; Bjork, Anna ; Anderson, David ; Speake, Cate ; Ruchaud, Emily ; Skinner, Jason ; Alsina, Laia ; Sharma, Mamta ; Dutartre, Helene ; Cepika, Alma ; Israelsson, Elisabeth ; Nguyen, Phuong ; Nguyen, Quynh Anh ; Harrod, A. Carson ; Zurawski, Sandra M. ; Pascual, Virginia ; Ueno, Hideki ; Nepom, Gerald T. ; Quinn, Charlie ; Blankenship, Derek ; Palucka, Karolina ; Banchereau, Jacques ; Chaussabel, Damien J. / Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines. In: Immunity. 2013 ; Vol. 38, No. 4. pp. 831-844.
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AU - Anderson, David

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AU - Israelsson, Elisabeth

AU - Nguyen, Phuong

AU - Nguyen, Quynh Anh

AU - Harrod, A. Carson

AU - Zurawski, Sandra M.

AU - Pascual, Virginia

AU - Ueno, Hideki

AU - Nepom, Gerald T.

AU - Quinn, Charlie

AU - Blankenship, Derek

AU - Palucka, Karolina

AU - Banchereau, Jacques

AU - Chaussabel, Damien J.

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