Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines

Gerlinde Obermoser, Scott Presnell, Kelly Domico, Hui Xu, Yuanyuan Wang, Esperanza Anguiano, Lu Ann Thompson-Snipes, Rajaram Ranganathan, Brad Zeitner, Anna Bjork, David Anderson, Cate Speake, Emily Ruchaud, Jason Skinner, Laia Alsina, Mamta Sharma, Helene Dutartre, Alma Cepika, Elisabeth Israelsson, Phuong NguyenQuynh Anh Nguyen, A. Carson Harrod, Sandra M. Zurawski, Virginia Pascual, Hideki Ueno, Gerald T. Nepom, Charlie Quinn, Derek Blankenship, Karolina Palucka, Jacques Banchereau, Damien Chaussabel

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162 Citations (Scopus)

Abstract

Systems immunology approaches were employed to investigate innate and adaptive immune responses to influenza and pneumococcal vaccines. These two non-live vaccines show different magnitudes of transcriptional responses at different time points after vaccination. Software solutions were developed to explore correlates of vaccine efficacy measured as antibody titers at day 28. These enabled a further dissection of transcriptional responses. Thus, the innate response, measured within hours in the peripheral blood, was dominated by an interferon transcriptional signature after influenza vaccination and by an inflammation signature after pneumococcal vaccination. Day 7 plasmablast responses induced by both vaccines was more pronounced after pneumococcal vaccination. Together, these results suggest that comparing global immune responses elicited by different vaccines will be critical to our understanding of the immune mechanisms underpinning successful vaccination.

Original languageEnglish
Pages (from-to)831-844
Number of pages14
JournalImmunity
Volume38
Issue number4
DOIs
Publication statusPublished - 18 Apr 2013

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Obermoser, G., Presnell, S., Domico, K., Xu, H., Wang, Y., Anguiano, E., Thompson-Snipes, L. A., Ranganathan, R., Zeitner, B., Bjork, A., Anderson, D., Speake, C., Ruchaud, E., Skinner, J., Alsina, L., Sharma, M., Dutartre, H., Cepika, A., Israelsson, E., ... Chaussabel, D. (2013). Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines. Immunity, 38(4), 831-844. https://doi.org/10.1016/j.immuni.2012.12.008