Systematic evaluation of immune regulation and modulation

David F. Stroncek, Lisa H. Butterfield, Michael A. Cannarile, Madhav V. Dhodapkar, Tim F. Greten, Jean-Charles B. Grivel, David R. Kaufman, Heidi H. Kong, Firouzeh Korangy, Peter P. Lee, Francesco Marincola, Sergio Rutella, Janet C. Siebert, Giorgio Trinchieri, Barbara Seliger

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Cancer immunotherapies are showing promising clinical results in a variety of malignancies. Monitoring the immune as well as the tumor response following these therapies has led to significant advancements in the field. Moreover, the identification and assessment of both predictive and prognostic biomarkers has become a key component to advancing these therapies. Thus, it is critical to develop systematic approaches to monitor the immune response and to interpret the data obtained from these assays. In order to address these issues and make recommendations to the field, the Society for Immunotherapy of Cancer reconvened the Immune Biomarkers Task Force. As a part of this Task Force, Working Group 3 (WG3) consisting of multidisciplinary experts from industry, academia, and government focused on the systematic assessment of immune regulation and modulation. In this review, the tumor microenvironment, microbiome, bone marrow, and adoptively transferred T cells will be used as examples to discuss the type and timing of sample collection. In addition, potential types of measurements, assays, and analyses will be discussed for each sample. Specifically, these recommendations will focus on the unique collection and assay requirements for the analysis of various samples as well as the high-throughput assays to evaluate potential biomarkers.

Original languageEnglish
Article number21
JournalJournal for ImmunoTherapy of Cancer
Volume5
Issue number1
DOIs
Publication statusPublished - 21 Mar 2017

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Keywords

  • High-throughput
  • Immune biomarkers
  • Immune regulation
  • Systematic monitoring

ASJC Scopus subject areas

  • Oncology
  • Immunology and Allergy
  • Cancer Research
  • Molecular Medicine
  • Pharmacology
  • Immunology

Cite this

Stroncek, D. F., Butterfield, L. H., Cannarile, M. A., Dhodapkar, M. V., Greten, T. F., Grivel, J-C. B., Kaufman, D. R., Kong, H. H., Korangy, F., Lee, P. P., Marincola, F., Rutella, S., Siebert, J. C., Trinchieri, G., & Seliger, B. (2017). Systematic evaluation of immune regulation and modulation. Journal for ImmunoTherapy of Cancer, 5(1), [21]. https://doi.org/10.1186/s40425-017-0223-8