Synthesis of ferrocenoyl amino acid derivatives via homogeneous catalytic aminocarbonylation

Árpád Kuik, Rita Skoda-Földes, János Balogh, László Kollár

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20 Citations (Scopus)

Abstract

Palladium-catalysed aminocarbonylation of iodoferrocene with amino acid esters as nucleophiles results in the selective formation of N-ferrocenoyl amino acid esters in the presence of Et3N as the base. At the same time, the use of DBU leads to the formation of new N-ferrocenylglyoxyl amino acid derivatives with reasonable selectivity. In the latter reactions two new side products, formed via acylation of DBU, were also isolated and characterised.

Original languageEnglish
Pages (from-to)3237-3242
Number of pages6
JournalJournal of Organometallic Chemistry
Volume690
Issue number13
DOIs
Publication statusPublished - 1 Jul 2005
Externally publishedYes

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Keywords

  • α-Ketoamides
  • Amino acids
  • Carbonylation
  • Ferrocene
  • Pd-catalysts

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Materials Science (miscellaneous)
  • Materials Chemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry
  • Biochemistry

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