The water-energy nexus and integration has been recently proposed to minimize water-energy footprint of an industrial park. Their sustainable design requires careful consideration of energy and water management aspects. This work represents an integrated management across the water and energy nexus. We propose an optimization-based methodology, which considers main decision across the water-energy nexus for industrial clusters. Building on our previous work in industrial water networks, a representation is generated that accounts for the links between water and energy. In this work, the Tool for the Reduction and Assessment of Chemical and other environmental Impacts (TRACI) metrics have been used in order to quantify some of the environmental emissions. Global warming and eco-toxicity impacts are the ones, which are calculated for the optimized design. Pareto front curves are generated for a case study in order to capture the trade-offs between the minimum total annual cost and environmental sustainability metrics.