Sural nerve biopsy may predict future nerve dysfunction

S. Thrainsdottir, Rayaz Malik, I. Rosén, F. Jakobsson, E. Bakhtadze, J. Petersson, G. Sundkvist, L. B. Dahlin

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective - Sural nerve pathology in peripheral neuropathy shows correlation with clinical findings and neurophysiological tests. The aim was to investigate progression of nerve dysfunction over time in relation to a baseline nerve biopsy. Methods - Baseline myelinated nerve fiber density (MNFD) was assessed in sural nerve biopsies from 10 men with type 2 diabetes, 10 with impaired and 10 with normal glucose tolerance. Nerve conduction and quantitative perception thresholds were estimated at baseline and follow-up (7-10 years later). Results - Subjects with low MNFD (≤4700 fibers/mm2) showed decline of peroneal amplitude (P < 0.02) and conduction velocity (P < 0.04), as well as median nerve sensory amplitude (P < 0.05) and motor conduction velocity (P < 0.04) from baseline to follow-up. In linear regression analyses, diabetes influenced decline of nerve conduction. MNFD correlated negatively with body mass index (r = -0.469; P < 0.02). Conclusion - Low MNFD may predict progression of neurophysiological dysfunction and links obesity to myelinated nerve fiber loss.

Original languageEnglish
Pages (from-to)38-46
Number of pages9
JournalActa Neurologica Scandinavica
Volume120
Issue number1
DOIs
Publication statusPublished - Jul 2009
Externally publishedYes

Fingerprint

Myelinated Nerve Fibers
Sural Nerve
Biopsy
Neural Conduction
Median Nerve
Peripheral Nervous System Diseases
Type 2 Diabetes Mellitus
Linear Models
Body Mass Index
Obesity
Regression Analysis
Pathology
Glucose

Keywords

  • Body mass index
  • Diabetic neuropathy
  • Nerve conduction
  • Quantitative sensory thresholds
  • Sural nerve pathology

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Thrainsdottir, S., Malik, R., Rosén, I., Jakobsson, F., Bakhtadze, E., Petersson, J., ... Dahlin, L. B. (2009). Sural nerve biopsy may predict future nerve dysfunction. Acta Neurologica Scandinavica, 120(1), 38-46. https://doi.org/10.1111/j.1600-0404.2008.01118.x

Sural nerve biopsy may predict future nerve dysfunction. / Thrainsdottir, S.; Malik, Rayaz; Rosén, I.; Jakobsson, F.; Bakhtadze, E.; Petersson, J.; Sundkvist, G.; Dahlin, L. B.

In: Acta Neurologica Scandinavica, Vol. 120, No. 1, 07.2009, p. 38-46.

Research output: Contribution to journalArticle

Thrainsdottir, S, Malik, R, Rosén, I, Jakobsson, F, Bakhtadze, E, Petersson, J, Sundkvist, G & Dahlin, LB 2009, 'Sural nerve biopsy may predict future nerve dysfunction', Acta Neurologica Scandinavica, vol. 120, no. 1, pp. 38-46. https://doi.org/10.1111/j.1600-0404.2008.01118.x
Thrainsdottir S, Malik R, Rosén I, Jakobsson F, Bakhtadze E, Petersson J et al. Sural nerve biopsy may predict future nerve dysfunction. Acta Neurologica Scandinavica. 2009 Jul;120(1):38-46. https://doi.org/10.1111/j.1600-0404.2008.01118.x
Thrainsdottir, S. ; Malik, Rayaz ; Rosén, I. ; Jakobsson, F. ; Bakhtadze, E. ; Petersson, J. ; Sundkvist, G. ; Dahlin, L. B. / Sural nerve biopsy may predict future nerve dysfunction. In: Acta Neurologica Scandinavica. 2009 ; Vol. 120, No. 1. pp. 38-46.
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