Supramolecular Peptide Hydrogel-Based Soft Neural Interface Augments Brain Signals through a Three-Dimensional Electrical Network

Jiyoung Nam, Hyun Kyoung Lim, Nam Hyeong Kim, Jong Kwan Park, Eun Sung Kang, Yong Tae Kim, Chaejeong Heo, One Sun Lee, Seong Gi Kim, Wan Soo Yun, Minah Suh, Yong Ho Kim

Research output: Contribution to journalArticle

Abstract

Recording neural activity from the living brain is of great interest in neuroscience for interpreting cognitive processing or neurological disorders. Despite recent advances in neural technologies, development of a soft neural interface that integrates with neural tissues, increases recording sensitivity, and prevents signal dissipation still remains a major challenge. Here, we introduce a biocompatible, conductive, and biostable neural interface, a supramolecular β-peptide-based hydrogel that allows signal amplification via tight neural/hydrogel contact without neuroinflammation. The non-biodegradable β-peptide forms a multihierarchical structure with conductive nanomaterial, creating a three-dimensional electrical network, which can augment brain signal efficiently. By achieving seamless integration in brain tissue with increased contact area and tight neural tissue coupling, the epidural and intracortical neural signals recorded with the hydrogel were augmented, especially in the high frequency range. Overall, our tissuelike chronic neural interface will facilitate a deeper understanding of brain oscillation in broad brain states and further lead to more efficient brain-computer interfaces.

Original languageEnglish
Pages (from-to)664-675
Number of pages12
JournalACS Nano
Volume14
Issue number1
DOIs
Publication statusPublished - 28 Jan 2020

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Keywords

  • brain signals
  • carbon nanotube
  • hydrogel-based neural interface
  • supramolecular peptide
  • three-dimensional electrical network

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Nam, J., Lim, H. K., Kim, N. H., Park, J. K., Kang, E. S., Kim, Y. T., Heo, C., Lee, O. S., Kim, S. G., Yun, W. S., Suh, M., & Kim, Y. H. (2020). Supramolecular Peptide Hydrogel-Based Soft Neural Interface Augments Brain Signals through a Three-Dimensional Electrical Network. ACS Nano, 14(1), 664-675. https://doi.org/10.1021/acsnano.9b07396