Sugar alcohol provides imaging contrast in cancer detection

Puneet Bagga, Neil Wilson, Laurie Rich, Francesco M. Marincola, Mitchell D. Schnall, Hari Hariharan, Mohammad Haris, Ravinder Reddy

Research output: Contribution to journalArticle

Abstract

Clinical imaging is widely used to detect, characterize and stage cancers in addition to monitoring the therapeutic progress. Magnetic resonance imaging (MRI) aided by contrast agents utilizes the differential relaxivity property of water to distinguish between tumorous and normal tissue. Here, we describe an MRI contrast method for the detection of cancer using a sugar alcohol, maltitol, a common low caloric sugar substitute that exploits the chemical exchange saturation transfer (CEST) property of the labile hydroxyl group protons on maltitol (malCEST). In vitro studies pointed toward concentration and pH-dependent CEST effect peaking at 1 ppm downfield to the water resonance. Studies with control rats showed that intravenously injected maltitol does not cross the intact blood-brain barrier (BBB). In glioma carrying rats, administration of maltitol resulted in the elevation of CEST contrast in the tumor region only owing to permeable BBB. These preliminary results show that this method may lead to the development of maltitol and other sugar alcohol derivatives as MRI contrast agents for a variety of preclinical imaging applications.

Original languageEnglish
Number of pages1
JournalScientific reports
Volume9
Issue number1
DOIs
Publication statusPublished - 31 Jul 2019

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Sugar Alcohols
Magnetic Resonance Imaging
Neoplasms
Blood-Brain Barrier
Contrast Media
Sweetening Agents
Water
Glioma
Hydroxyl Radical
Protons
maltitol

ASJC Scopus subject areas

  • General

Cite this

Bagga, P., Wilson, N., Rich, L., Marincola, F. M., Schnall, M. D., Hariharan, H., ... Reddy, R. (2019). Sugar alcohol provides imaging contrast in cancer detection. Scientific reports, 9(1). https://doi.org/10.1038/s41598-019-47275-5

Sugar alcohol provides imaging contrast in cancer detection. / Bagga, Puneet; Wilson, Neil; Rich, Laurie; Marincola, Francesco M.; Schnall, Mitchell D.; Hariharan, Hari; Haris, Mohammad; Reddy, Ravinder.

In: Scientific reports, Vol. 9, No. 1, 31.07.2019.

Research output: Contribution to journalArticle

Bagga, P, Wilson, N, Rich, L, Marincola, FM, Schnall, MD, Hariharan, H, Haris, M & Reddy, R 2019, 'Sugar alcohol provides imaging contrast in cancer detection', Scientific reports, vol. 9, no. 1. https://doi.org/10.1038/s41598-019-47275-5
Bagga P, Wilson N, Rich L, Marincola FM, Schnall MD, Hariharan H et al. Sugar alcohol provides imaging contrast in cancer detection. Scientific reports. 2019 Jul 31;9(1). https://doi.org/10.1038/s41598-019-47275-5
Bagga, Puneet ; Wilson, Neil ; Rich, Laurie ; Marincola, Francesco M. ; Schnall, Mitchell D. ; Hariharan, Hari ; Haris, Mohammad ; Reddy, Ravinder. / Sugar alcohol provides imaging contrast in cancer detection. In: Scientific reports. 2019 ; Vol. 9, No. 1.
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