Studies of the desensitization of atrial natriuretic factor and nitroglycerin in rat aortic rings

A. J. Rankin, T. M. McWilliam, F. V. Swift, Christopher Triggle

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

1. 1. Atrial natriuretic factor (ANF) relaxes vascular smooth muscle through activation of particulate guanylate cyclase and generation of cyclic GMP. 2. 2. From other laboratories, there is some evidence from cultured vascular smooth muscle cell studies for homologous desensitization of ANF-induced cGMP production and down-regulation of ANF receptors. 3. 3. This series of studies demonstrates that homologous desensitization of ANF-induced relaxation of rat aortic ring preparations also occurs. 4. 4. Heterologous desensitization could not be demonstrated to the vasoactive peptides angiotensin II or vasopressin, nor to nitroglycerin which has previously been shown to exhibit heterologous desensitization with other nitrovasodilators and shares some common elements in the pathway to vascular smooth muscle relaxation with ANF.

Original languageEnglish
Pages (from-to)887-891
Number of pages5
JournalGeneral Pharmacology
Volume21
Issue number6
DOIs
Publication statusPublished - 1990
Externally publishedYes

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Nitroglycerin
Atrial Natriuretic Factor
Vascular Smooth Muscle
Atrial Natriuretic Factor Receptors
Muscle Relaxation
Guanylate Cyclase
Cyclic GMP
Vasopressins
Angiotensin II
Smooth Muscle Myocytes
Down-Regulation
Peptides

ASJC Scopus subject areas

  • Pharmacology

Cite this

Studies of the desensitization of atrial natriuretic factor and nitroglycerin in rat aortic rings. / Rankin, A. J.; McWilliam, T. M.; Swift, F. V.; Triggle, Christopher.

In: General Pharmacology, Vol. 21, No. 6, 1990, p. 887-891.

Research output: Contribution to journalArticle

Rankin, A. J. ; McWilliam, T. M. ; Swift, F. V. ; Triggle, Christopher. / Studies of the desensitization of atrial natriuretic factor and nitroglycerin in rat aortic rings. In: General Pharmacology. 1990 ; Vol. 21, No. 6. pp. 887-891.
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