Structure and function insights into the NuRD chromatin remodeling complex

Morgan P. Torchy, Ali Hamiche, Bruno P. Klaholz

Research output: Contribution to journalReview article

54 Citations (Scopus)

Abstract

Transcription regulation through chromatin compaction and decompaction is regulated through various chromatin-remodeling complexes such as nucleosome remodeling and histone deacetylation (NuRD) complex. NuRD is a 1 MDa multi-subunit protein complex which comprises many different subunits, among which histone deacetylases HDAC1/2, ATP-dependent remodeling enzymes CHD3/4, histone chaperones RbAp46/48, CpG-binding proteins MBD2/3, the GATAD2a (p66α) and/or GATAD2b (p66β) and specific DNA-binding proteins MTA1/2/3. Here, we review the currently known crystal and NMR structures of these subunits, the functional data and their relevance for biomedical research considering the implication of NuRD subunits in cancer and various other diseases. The complexity of this macromolecular assembly, and its poorly understood mode of interaction with the nucleosome, the repeating unit of chromatin, illustrate that this complex is a major challenge for structure-function relationship studies which will be tackled best by an integrated biology approach.

Original languageEnglish
Pages (from-to)2491-2507
Number of pages17
JournalCellular and Molecular Life Sciences
Volume72
Issue number13
DOIs
Publication statusPublished - 8 Jul 2015
Externally publishedYes

Fingerprint

Chromatin Assembly and Disassembly
Nucleosomes
Histones
Chromatin
Histone Chaperones
Histone Deacetylases
Protein Subunits
DNA-Binding Proteins
Biomedical Research
Carrier Proteins
Adenosine Triphosphate
Enzymes
Neoplasms

Keywords

  • Chromatin
  • Deacetylase
  • Nucleosome
  • NuRD
  • Remodeling
  • Structural biology

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

Structure and function insights into the NuRD chromatin remodeling complex. / Torchy, Morgan P.; Hamiche, Ali; Klaholz, Bruno P.

In: Cellular and Molecular Life Sciences, Vol. 72, No. 13, 08.07.2015, p. 2491-2507.

Research output: Contribution to journalReview article

Torchy, Morgan P. ; Hamiche, Ali ; Klaholz, Bruno P. / Structure and function insights into the NuRD chromatin remodeling complex. In: Cellular and Molecular Life Sciences. 2015 ; Vol. 72, No. 13. pp. 2491-2507.
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