Structural properties of pore-forming oligomers of α-synuclein

Hai Young Kim, Min Kyu Cho, Ashutosh Kumar, Elke Maier, Carsten Siebenhaar, Stefan Becker, Claudio O. Fernandez, Hilal A. Lashuel, Roland Benz, Adam Lange, Markus Zweckstetter

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

Soluble oligomers are potent toxins in many neurodegenerative diseases, but little is known about the structure of soluble oligomers and their structure-toxicity relationship. Here we prepared on-pathway oligomers of the 140-residue protein α-synuclein, a key player in Parkinson's disease, at concentrations an order of magnitude higher than previously possible. The oligomers form ion channels with well-defined conductance states in a variety of membranes, and their β-structure differs from that of amyloid fibrils of α-synuclein.

Original languageEnglish
Pages (from-to)17482-17489
Number of pages8
JournalJournal of the American Chemical Society
Volume131
Issue number47
DOIs
Publication statusPublished - 2 Dec 2009
Externally publishedYes

Fingerprint

Synucleins
Oligomers
Structural properties
Ion Channels
Amyloid
Neurodegenerative Diseases
Parkinson Disease
Neurodegenerative diseases
Membranes
Toxicity
Proteins
Ions

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Kim, H. Y., Cho, M. K., Kumar, A., Maier, E., Siebenhaar, C., Becker, S., ... Zweckstetter, M. (2009). Structural properties of pore-forming oligomers of α-synuclein. Journal of the American Chemical Society, 131(47), 17482-17489. https://doi.org/10.1021/ja9077599

Structural properties of pore-forming oligomers of α-synuclein. / Kim, Hai Young; Cho, Min Kyu; Kumar, Ashutosh; Maier, Elke; Siebenhaar, Carsten; Becker, Stefan; Fernandez, Claudio O.; Lashuel, Hilal A.; Benz, Roland; Lange, Adam; Zweckstetter, Markus.

In: Journal of the American Chemical Society, Vol. 131, No. 47, 02.12.2009, p. 17482-17489.

Research output: Contribution to journalArticle

Kim, HY, Cho, MK, Kumar, A, Maier, E, Siebenhaar, C, Becker, S, Fernandez, CO, Lashuel, HA, Benz, R, Lange, A & Zweckstetter, M 2009, 'Structural properties of pore-forming oligomers of α-synuclein', Journal of the American Chemical Society, vol. 131, no. 47, pp. 17482-17489. https://doi.org/10.1021/ja9077599
Kim HY, Cho MK, Kumar A, Maier E, Siebenhaar C, Becker S et al. Structural properties of pore-forming oligomers of α-synuclein. Journal of the American Chemical Society. 2009 Dec 2;131(47):17482-17489. https://doi.org/10.1021/ja9077599
Kim, Hai Young ; Cho, Min Kyu ; Kumar, Ashutosh ; Maier, Elke ; Siebenhaar, Carsten ; Becker, Stefan ; Fernandez, Claudio O. ; Lashuel, Hilal A. ; Benz, Roland ; Lange, Adam ; Zweckstetter, Markus. / Structural properties of pore-forming oligomers of α-synuclein. In: Journal of the American Chemical Society. 2009 ; Vol. 131, No. 47. pp. 17482-17489.
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