Structural genomic abnormalities of chromosomes 9 and 18 in myxopapillary ependymomas

Maria Betania Mahler-Araujo, Despina Sanoudou, Ola Tingby, Lu Liu, Nicholas Coleman, Koichi Ichimura, Vincent Peter Collins

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    Abstract

    Myxopapillary ependymomas (MPEs) are low-grade neuroepithelial tumors typically occurring in the conus - cauda equina - filum terminale region. Limited molecular and cytogenetic analysis of MPEs has not demonstrated consistent abnormalities. In an attempt to clarify the chromosomal status of these tumors and identify commonly aberrant regions in the genome we have combined 3 molecular/cyto/genetic methods to study 17 MPEs. Comparative genomic hybridization of 7/17 tumors identified concurrent gain on chromosomes 9 and 18 as the most frequent finding. The majority of the 17 tumors were also studied using microsatellite analysis with marker spanning the whole chromosomes 9 and 18 and interphase-FISH with centromeric probes for both chromosomes. Our combined results were consistent with concurrent gain in both chromosomes 9 and 18 in 11/17 cases, gain of either chromosome 9 or 18 and imbalance in the other chromosome in 3/17 tumors and allelic imbalances of chromosomes 9 or 18 in 3/17 and 1/17 tumors, respectively. Other abnormalities observed included gain of chromosomes 3, 4, 7, 8, 11, 13, 17q, 20, and X and loss of chromosomes 10 and 22. Our findings represent some steps towards understanding the molecular mechanisms involved in the development of MPE.

    Original languageEnglish
    Pages (from-to)927-935
    Number of pages9
    JournalJournal of Neuropathology and Experimental Neurology
    Volume62
    Issue number9
    DOIs
    Publication statusPublished - 1 Sep 2003

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    Keywords

    • Aneusomy
    • Central nervous system tumors
    • Comparative genomic hybridization
    • Fluorescence in situ hybridization
    • Microsatellite analysis
    • Polysomy

    ASJC Scopus subject areas

    • Pathology and Forensic Medicine
    • Neurology
    • Clinical Neurology
    • Cellular and Molecular Neuroscience

    Cite this

    Mahler-Araujo, M. B., Sanoudou, D., Tingby, O., Liu, L., Coleman, N., Ichimura, K., & Collins, V. P. (2003). Structural genomic abnormalities of chromosomes 9 and 18 in myxopapillary ependymomas. Journal of Neuropathology and Experimental Neurology, 62(9), 927-935. https://doi.org/10.1093/jnen/62.9.927