Structural features of U6 snRNA and dynamic interactions with other spliceosomal components leading to pre-mRNA splicing

T. Forné, E. Labourier, E. Antoine, F. Rossi, Imed Gallouzi, G. Cathala, J. Tazi, C. Brunel

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

In the spliceosome, the pre-mRNA, U2 and U6 snRNAs fold into a catalytic structure exhibiting striking similarities with domain V and VI of group II introns. Building of this tripartite structure implies that an evolutionary conserved base pairing between U4 and U6 snRNAs should be disrupted to allow potentially U6 catalytic residue to interact with U2 snRNAs and the pre-mRNA. The steps leading to U4/U6 disruption have been recently discovered and have been shown to involve a modification of the 3' end of U6 snRNA and the hnRNP C protein.

Original languageEnglish
Pages (from-to)436-442
Number of pages7
JournalBiochimie
Volume78
Issue number6
DOIs
Publication statusPublished - 1996
Externally publishedYes

Fingerprint

RNA Precursors
Heterogeneous-Nuclear Ribonucleoprotein Group C
Spliceosomes
Base Pairing
Introns
U6 small nuclear RNA

Keywords

  • 3' end modifications of U6 snRNA
  • Pre-messenger RNA
  • Splicing
  • U snRNAs

ASJC Scopus subject areas

  • Biochemistry

Cite this

Structural features of U6 snRNA and dynamic interactions with other spliceosomal components leading to pre-mRNA splicing. / Forné, T.; Labourier, E.; Antoine, E.; Rossi, F.; Gallouzi, Imed; Cathala, G.; Tazi, J.; Brunel, C.

In: Biochimie, Vol. 78, No. 6, 1996, p. 436-442.

Research output: Contribution to journalReview article

Forné, T. ; Labourier, E. ; Antoine, E. ; Rossi, F. ; Gallouzi, Imed ; Cathala, G. ; Tazi, J. ; Brunel, C. / Structural features of U6 snRNA and dynamic interactions with other spliceosomal components leading to pre-mRNA splicing. In: Biochimie. 1996 ; Vol. 78, No. 6. pp. 436-442.
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AU - Forné, T.

AU - Labourier, E.

AU - Antoine, E.

AU - Rossi, F.

AU - Gallouzi, Imed

AU - Cathala, G.

AU - Tazi, J.

AU - Brunel, C.

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