Stress-related and circadian secretion and target tissue actions of glucocorticoids: Impact on health

Nicolas C. Nicolaides, Evangelia Charmandari, Tomoshige Kino, George P. Chrousos

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Living organisms are highly complex systems that must maintain a dynamic equilibrium or homeostasis that requires energy to be sustained. Stress is a state in which several extrinsic or intrinsic disturbing stimuli, the stressors, threaten, or are perceived as threatening, homeostasis. To achieve homeostasis against the stressors, organisms have developed a highly sophisticated system, the stress system, which provides neuroendocrine adaptive responses, to restore homeostasis. These responses must be appropriate in terms of size and/or duration; otherwise, they may sustain life but be associated with detrimental effects on numerous physiologic functions of the organism, leading to a state of disease-causing disturbed homeostasis or cacostasis. In addition to facing a broad spectrum of external and/or internal stressors, organisms are subject to recurring environmental changes associated with the rotation of the planet around itself and its revolution around the sun. To adjust their homeostasis and to synchronize their activities to day/night cycles, organisms have developed an evolutionarily conserved biologic system, the "clock" system, which influences several physiologic functions in a circadian fashion. Accumulating evidence suggests that the stress system is intimately related to the circadian clock system, with dysfunction of the former resulting in dysregulation of the latter and vice versa. In this review, we describe the functional components of the two systems, we discuss their multilevel interactions, and we present how excessive or prolonged activity of the stress system affects the circadian rhythm of glucocorticoid secretion and target tissue effects.

Original languageEnglish
Article number70
JournalFrontiers in Endocrinology
Volume8
Issue numberAPR
DOIs
Publication statusPublished - 28 Apr 2017

Fingerprint

Glucocorticoids
Homeostasis
Health
Biological Clocks
Planets
Circadian Clocks
Solar System
Circadian Rhythm

Keywords

  • Circadian endocrine rhythms
  • Clock system
  • Glucocorticoid receptor
  • Glucocorticoids
  • Hypothalamic-pituitary-adrenal axis
  • Stress
  • Stress system

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Stress-related and circadian secretion and target tissue actions of glucocorticoids : Impact on health. / Nicolaides, Nicolas C.; Charmandari, Evangelia; Kino, Tomoshige; Chrousos, George P.

In: Frontiers in Endocrinology, Vol. 8, No. APR, 70, 28.04.2017.

Research output: Contribution to journalReview article

Nicolaides, Nicolas C. ; Charmandari, Evangelia ; Kino, Tomoshige ; Chrousos, George P. / Stress-related and circadian secretion and target tissue actions of glucocorticoids : Impact on health. In: Frontiers in Endocrinology. 2017 ; Vol. 8, No. APR.
@article{3916bf44b69f461f92b0b45bb566b442,
title = "Stress-related and circadian secretion and target tissue actions of glucocorticoids: Impact on health",
abstract = "Living organisms are highly complex systems that must maintain a dynamic equilibrium or homeostasis that requires energy to be sustained. Stress is a state in which several extrinsic or intrinsic disturbing stimuli, the stressors, threaten, or are perceived as threatening, homeostasis. To achieve homeostasis against the stressors, organisms have developed a highly sophisticated system, the stress system, which provides neuroendocrine adaptive responses, to restore homeostasis. These responses must be appropriate in terms of size and/or duration; otherwise, they may sustain life but be associated with detrimental effects on numerous physiologic functions of the organism, leading to a state of disease-causing disturbed homeostasis or cacostasis. In addition to facing a broad spectrum of external and/or internal stressors, organisms are subject to recurring environmental changes associated with the rotation of the planet around itself and its revolution around the sun. To adjust their homeostasis and to synchronize their activities to day/night cycles, organisms have developed an evolutionarily conserved biologic system, the {"}clock{"} system, which influences several physiologic functions in a circadian fashion. Accumulating evidence suggests that the stress system is intimately related to the circadian clock system, with dysfunction of the former resulting in dysregulation of the latter and vice versa. In this review, we describe the functional components of the two systems, we discuss their multilevel interactions, and we present how excessive or prolonged activity of the stress system affects the circadian rhythm of glucocorticoid secretion and target tissue effects.",
keywords = "Circadian endocrine rhythms, Clock system, Glucocorticoid receptor, Glucocorticoids, Hypothalamic-pituitary-adrenal axis, Stress, Stress system",
author = "Nicolaides, {Nicolas C.} and Evangelia Charmandari and Tomoshige Kino and Chrousos, {George P.}",
year = "2017",
month = "4",
day = "28",
doi = "10.3389/fendo.2017.00070",
language = "English",
volume = "8",
journal = "Frontiers in Endocrinology",
issn = "1664-2392",
publisher = "Frontiers Media S. A.",
number = "APR",

}

TY - JOUR

T1 - Stress-related and circadian secretion and target tissue actions of glucocorticoids

T2 - Impact on health

AU - Nicolaides, Nicolas C.

AU - Charmandari, Evangelia

AU - Kino, Tomoshige

AU - Chrousos, George P.

PY - 2017/4/28

Y1 - 2017/4/28

N2 - Living organisms are highly complex systems that must maintain a dynamic equilibrium or homeostasis that requires energy to be sustained. Stress is a state in which several extrinsic or intrinsic disturbing stimuli, the stressors, threaten, or are perceived as threatening, homeostasis. To achieve homeostasis against the stressors, organisms have developed a highly sophisticated system, the stress system, which provides neuroendocrine adaptive responses, to restore homeostasis. These responses must be appropriate in terms of size and/or duration; otherwise, they may sustain life but be associated with detrimental effects on numerous physiologic functions of the organism, leading to a state of disease-causing disturbed homeostasis or cacostasis. In addition to facing a broad spectrum of external and/or internal stressors, organisms are subject to recurring environmental changes associated with the rotation of the planet around itself and its revolution around the sun. To adjust their homeostasis and to synchronize their activities to day/night cycles, organisms have developed an evolutionarily conserved biologic system, the "clock" system, which influences several physiologic functions in a circadian fashion. Accumulating evidence suggests that the stress system is intimately related to the circadian clock system, with dysfunction of the former resulting in dysregulation of the latter and vice versa. In this review, we describe the functional components of the two systems, we discuss their multilevel interactions, and we present how excessive or prolonged activity of the stress system affects the circadian rhythm of glucocorticoid secretion and target tissue effects.

AB - Living organisms are highly complex systems that must maintain a dynamic equilibrium or homeostasis that requires energy to be sustained. Stress is a state in which several extrinsic or intrinsic disturbing stimuli, the stressors, threaten, or are perceived as threatening, homeostasis. To achieve homeostasis against the stressors, organisms have developed a highly sophisticated system, the stress system, which provides neuroendocrine adaptive responses, to restore homeostasis. These responses must be appropriate in terms of size and/or duration; otherwise, they may sustain life but be associated with detrimental effects on numerous physiologic functions of the organism, leading to a state of disease-causing disturbed homeostasis or cacostasis. In addition to facing a broad spectrum of external and/or internal stressors, organisms are subject to recurring environmental changes associated with the rotation of the planet around itself and its revolution around the sun. To adjust their homeostasis and to synchronize their activities to day/night cycles, organisms have developed an evolutionarily conserved biologic system, the "clock" system, which influences several physiologic functions in a circadian fashion. Accumulating evidence suggests that the stress system is intimately related to the circadian clock system, with dysfunction of the former resulting in dysregulation of the latter and vice versa. In this review, we describe the functional components of the two systems, we discuss their multilevel interactions, and we present how excessive or prolonged activity of the stress system affects the circadian rhythm of glucocorticoid secretion and target tissue effects.

KW - Circadian endocrine rhythms

KW - Clock system

KW - Glucocorticoid receptor

KW - Glucocorticoids

KW - Hypothalamic-pituitary-adrenal axis

KW - Stress

KW - Stress system

UR - http://www.scopus.com/inward/record.url?scp=85018239929&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018239929&partnerID=8YFLogxK

U2 - 10.3389/fendo.2017.00070

DO - 10.3389/fendo.2017.00070

M3 - Review article

AN - SCOPUS:85018239929

VL - 8

JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

SN - 1664-2392

IS - APR

M1 - 70

ER -